Lee Jungwook, Cho Heeyoon, Kang Minho, Hong Rimkyung, Seong Mincheol, Shin Yongun
Department of Ophthalmology, College of Medicine, Hanyang University, Seoul 04763, Korea.
J Clin Med. 2021 Nov 21;10(22):5436. doi: 10.3390/jcm10225436.
This study aimed to evaluate and compare the retinal and choroidal thickness and vessel density (VD) changes between silicone oil (SO) tamponade and after SO removal using swept-source optical coherence tomography (SS-OCT) and OCT angiography (OCTA). Thirty patients who underwent pars plana vitrectomy for retinal detachment (RD) with SO tamponade were included. SS-OCT and OCTA were conducted before RD surgery, during SO tamponade, and after SO removal. A 3-dimensional volumetric wide scan protocol was used for the analysis. The segmented retina, choroidal thickness map, and peripapillary thickness were then measured. For the OCTA analysis, 4.5 × 4.5 mm scans were used. Superficial and deep capillary plexus VDs in unaffected fellow eyes and eyes after SO removal were compared. During the SO tamponade period, the thickness of the parafoveal total retina, ganglion cell-inner plexiform layer, and peripapillary retinal nerve fiber layer (ppRNFL) were significantly thinner than those of unaffected fellow eyes ( < 0.05). The parafoveal layer thickness thinning recovered up to three to six months after SO removal. Moreover, six months after SO removal, the parafoveal thickness was not significantly different compared to that of unaffected fellow eyes ( > 0.05). However, the ppRNFL thickness was significantly decreased during SO tamponade and remained unrecovered six months after SO removal. There was no significant difference in the VD on the OCTA. Thus, SO tamponade and removal for RD resulted in a change in the retinal and peripapillary thickness. This may be due to the mechanical pressure effect of SO.
本研究旨在使用扫频光学相干断层扫描（SS-OCT）和光学相干断层扫描血管造影（OCTA）评估和比较硅油（SO）填塞期间及取出后视网膜和脉络膜厚度以及血管密度（VD）的变化。纳入了30例行玻璃体视网膜手术治疗视网膜脱离（RD）并使用SO填塞的患者。在RD手术前、SO填塞期间以及SO取出后进行SS-OCT和OCTA检查。采用三维容积宽扫描方案进行分析。然后测量分割后的视网膜、脉络膜厚度图和视乳头周围厚度。对于OCTA分析，采用4.5×4.5 mm扫描。比较未受影响的对侧眼和SO取出后眼的浅表和深层毛细血管丛VD。在SO填塞期间，黄斑旁全视网膜、神经节细胞-内丛状层和视乳头周围视网膜神经纤维层（ppRNFL）的厚度明显薄于未受影响的对侧眼（<0.05）。SO取出后三至六个月，黄斑旁层厚度变薄情况有所恢复。此外，SO取出六个月后，黄斑旁厚度与未受影响的对侧眼相比无显著差异（>0.05）。然而，SO填塞期间ppRNFL厚度明显降低，SO取出六个月后仍未恢复。OCTA上的VD无显著差异。因此，RD的SO填塞和取出导致视网膜和视乳头周围厚度发生变化。这可能是由于SO的机械压力作用。
