Lu Bing, Zhang Pengfei, Liu Haiyun, Jia Huixun, Yu Yang, Wang Fenghua, Wang Hong, Sun Xiaodong
Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China.
J Ophthalmol. 2021 Mar 23;2021:6621820. doi: 10.1155/2021/6621820. eCollection 2021.
To investigate the vascular density of the optic nerve head (ONH) and macula using optical coherence tomography angiography (OCTA) in patients undergoing vitrectomy for rhegmatogenous retinal detachment (RRD) and to evaluate associations with visual outcomes.
Patients with RRD, successfully treated with a pars plana vitrectomy (PPV) and a minimum three-month follow-up were included in this study. The vessel density (VD) of the ONH and peripapillary regions, foveal avascular zone (FAZ), foveal flow density (FFD), and parafoveal flow density (PFD) were evaluated using OCTA and compared to the fellow eye. Multivariate linear regression analysis was performed to determine correlations with visual outcomes.
Thirty-one patients with macula-off RRD were included in the study. Compared with the fellow eyes, eyes after RRD surgery had a lower peripapillary VD ( < 0.01). No significant difference in superficial and deep FFD, PFD, and FAZ area was found compared to the fellow eyes. Postoperative peripapillary VD and baseline BCVA were significantly associated with BCVA three months after PPV ( < 0.05).
Rhegmatogenous retinal detachment eyes successfully treated with PPV had lower peripapillary vessel density than fellow healthy eyes. Postoperative BCVA was related to postoperative peripapillary VD.
利用光学相干断层扫描血管造影（OCTA）研究接受玻璃体切除术治疗孔源性视网膜脱离（RRD）患者的视神经乳头（ONH）和黄斑的血管密度，并评估其与视觉预后的相关性。
本研究纳入了成功接受玻璃体切除术（PPV）且至少随访三个月的RRD患者。使用OCTA评估ONH及其周围区域的血管密度（VD）、黄斑无血管区（FAZ）、黄斑血流密度（FFD）和黄斑旁血流密度（PFD），并与对侧眼进行比较。进行多变量线性回归分析以确定与视觉预后的相关性。
31例黄斑脱离的RRD患者纳入研究。与对侧眼相比，RRD手术后的眼睛其视乳头周围VD较低（<0.01）。与对侧眼相比，浅表和深部FFD、PFD以及FAZ面积无显著差异。术后视乳头周围VD和基线最佳矫正视力（BCVA）与PPV术后三个月的BCVA显著相关（<0.05）。
成功接受PPV治疗的孔源性视网膜脱离眼，其视乳头周围血管密度低于对侧健康眼。术后BCVA与术后视乳头周围VD相关。
