Papaioannou Eleftheria, González-Molina María Del Pilar, Prieto-Muñoz Ana M, Gámez-Reche Laura, González-Martín Alicia
Department of Biochemistry, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), 28029 Madrid, Spain.
Cancers (Basel). 2021 Nov 12;13(22):5651. doi: 10.3390/cancers13225651.
Cancer immunology research has mainly focused on the role of protein-coding genes in regulating immune responses to tumors. However, despite more than 70% of the human genome is transcribed, less than 2% encodes proteins. Many non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have been identified as critical regulators of immune cell development and function, suggesting that they might play important roles in orchestrating immune responses against tumors. In this review, we summarize the scientific advances on the role of ncRNAs in regulating adaptive tumor immunity, and discuss their potential therapeutic value in the context of cancer immunotherapy.
癌症免疫学研究主要集中在蛋白质编码基因在调节肿瘤免疫反应中的作用。然而，尽管人类基因组转录率超过70%，但编码蛋白质的比例却不到2%。许多非编码RNA（ncRNA），包括微小RNA（miRNA）和长链非编码RNA（lncRNA），已被确定为免疫细胞发育和功能的关键调节因子，这表明它们可能在协调抗肿瘤免疫反应中发挥重要作用。在本综述中，我们总结了ncRNA在调节适应性肿瘤免疫方面的科学进展，并讨论了它们在癌症免疫治疗背景下的潜在治疗价值。
