Department of Occupational and Environmental Medicine, Gachon University Gil Medical Center, Incheon 21565, Korea.
Department of Preventive Medicine, Graduate School of Medicine, Gachon University, Incheon 21999, Korea.
Int J Environ Res Public Health. 2021 Nov 16;18(22):12005. doi: 10.3390/ijerph182212005.
Pyrethroid compounds are widely used in household insecticides and agricultural pesticides. Recent studies, however, report that pyrethroid exposures affect neurobehavioral function in animals and may be associated with adverse neurocognitive development in children. This study aimed to examine the association between pyrethroid exposure and cognitive dysfunction in older adults using a well-defined general population. We analyzed data from 336 individuals, aged 60-84 years, who participated in the National Health and Nutrition Examination Survey 2001-2002. We used urinary 3-phenoxybenzoic acid (3-PBA) concentration as a biomarker of pyrethroid exposures and assessed cognitive function with the digit-symbol coding test. The geometric means (±geometric standard errors) of creatinine-uncorrected and corrected urinary 3-PBA were 0.30 (±0.87) μg/L and 0.36 (±0.89) μg/g. After adjusting for sociodemographic factors, higher 3-PBA concentrations (> vs. ≤0.30 μg/g creatinine (median)) were associated with lower scores of cognitive function (-3.83 95% confidence interval: -7.11, -0.54). Significance was persistent after additionally adjusting for physical activity and smoking pack-year (-3.76 95% CI: -7.16, -0.36) and further adjusting for BMI and presence of hypertension and diabetes (-3.82 95% CI: -6.92, -0.71). Our findings suggest that pyrethroid exposure is associated with cognitive dysfunction in older adults.
拟除虫菊酯化合物广泛应用于家用杀虫剂和农业农药。然而，最近的研究报告称，拟除虫菊酯暴露会影响动物的神经行为功能，并且可能与儿童不良神经认知发育有关。本研究旨在使用明确的一般人群来研究拟除虫菊酯暴露与老年人认知功能障碍之间的关系。我们分析了参加 2001-2002 年全国健康和营养调查的 336 名年龄在 60-84 岁的个体的数据。我们使用尿 3-苯氧基苯甲酸（3-PBA）浓度作为拟除虫菊酯暴露的生物标志物，并使用数字符号编码测试评估认知功能。未校正和校正的尿 3-PBA 的几何平均值（±几何标准差）分别为 0.30（±0.87）μg/L 和 0.36（±0.89）μg/g。在校正了社会人口因素后，较高的 3-PBA 浓度（> vs. ≤0.30 μg/g 肌酐（中位数））与认知功能评分较低有关（-3.83 95%置信区间：-7.11，-0.54）。在进一步调整了体力活动和吸烟包年数（-3.76 95%CI：-7.16，-0.36）以及进一步调整了 BMI 和高血压和糖尿病的存在后，这种关联仍然存在（-3.82 95%CI：-6.92，-0.71）。我们的研究结果表明，拟除虫菊酯暴露与老年人的认知功能障碍有关。
