du Preez Ryan, Majzoub Marwan E, Thomas Torsten, Panchal Sunil K, Brown Lindsay
Functional Foods Research Group, University of Southern Queensland, Toowoomba, QLD 4350, Australia.
Centre for Marine Science and Innovation, University of New South Wales, Sydney, NSW 2052, Australia.
Metabolites. 2020 Dec 7;10(12):500. doi: 10.3390/metabo10120500.
(sea grapes) is widely consumed in South-East Asia as a low-energy food with high contents of vitamins and minerals. This study investigated dried sea grapes containing 16.6% insoluble fibre commercially produced in Vietnam as an intervention. We hypothesised that insoluble fibre is the primary metabolite that will reverse diet-induced metabolic syndrome. Male Wistar rats ( = 48) were randomly allocated to four groups in a 16 week protocol. Two groups were fed either corn starch (C) or high-carbohydrate, high-fat (H) diets for the full 16 weeks. The other two groups received C and H diets for eight weeks and then received added to these diets for the final eight weeks (CCL and HCL, respectively). High-carbohydrate, high-fat diet-fed rats developed obesity, hypertension, dyslipidaemia, fatty liver disease and increased left ventricular collagen deposition. supplementation in HCL rats decreased body weight, systolic blood pressure, plasma concentrations of total cholesterol and non-esterified fatty acids, inflammatory cells in heart and liver, and visceral adiposity. The Firmicutes to Bacteroidetes ratio decreased in the gut microbiota of HCL rats. Therefore, attenuated cardiovascular and metabolic symptoms of metabolic syndrome in rats, possibly by preventing infiltration of inflammatory cells together with modulating gut microbiota.
海葡萄在东南亚作为一种富含维生素和矿物质的低能量食物被广泛食用。本研究调查了越南商业化生产的含有16.6%不溶性纤维的干海葡萄作为一种干预措施。我们假设不溶性纤维是逆转饮食诱导的代谢综合征的主要代谢产物。将48只雄性Wistar大鼠随机分为四组，进行为期16周的实验。两组在整个16周内分别喂食玉米淀粉（C）或高碳水化合物、高脂肪（H）饮食。另外两组在前八周接受C和H饮食，然后在最后八周在这些饮食中添加（分别为CCL和HCL）。喂食高碳水化合物、高脂肪饮食的大鼠出现了肥胖、高血压、血脂异常、脂肪肝疾病以及左心室胶原沉积增加。在HCL大鼠中添加可降低体重、收缩压、总胆固醇和非酯化脂肪酸的血浆浓度、心脏和肝脏中的炎症细胞以及内脏脂肪。HCL大鼠肠道微生物群中厚壁菌门与拟杆菌门的比例降低。因此，可能通过防止炎症细胞浸润以及调节肠道微生物群，减轻了大鼠代谢综合征的心血管和代谢症状。
