Chen Nan-Fu, Su Yin-Di, Hwang Tsong-Long, Liao Zuo-Jian, Tsui Kuan-Hao, Wen Zhi-Hong, Wu Yang-Chang, Sung Ping-Jyun
Division of Neurosurgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 802, Taiwan.
Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.
Molecules. 2017 Mar 17;22(3):475. doi: 10.3390/molecules22030475.
Three new polyoxygenated briarane diterpenoids, briarenols C-E (-), were isolated from the octocoral . The structures of briaranes - were elucidated by interpretation of spectroscopic data, and the methylenecyclohexane ring in was found to exist in a twisted boat conformation. Briarenol D () displayed an inhibitory effect on the release of elastase by human neutrophils with an IC value of 4.65 μM. Briarenol E () was found to inhibit the protein expression of pro-inflammatory inducible nitric oxide synthase (iNOS) in a murine macrophage-like cell line, RAW 264.7, stimulated with lipopolysaccharides (LPS).
从八放珊瑚中分离出了三种新的多氧化蔷薇烷二萜类化合物，即蔷薇醇C - E（-）。通过光谱数据解析阐明了蔷薇烷类化合物的结构，并且发现化合物中的亚甲基环己烷环以扭曲船式构象存在。蔷薇醇D（）对人中性粒细胞释放弹性蛋白酶具有抑制作用，IC值为4.65μM。发现蔷薇醇E（）在脂多糖（LPS）刺激的小鼠巨噬细胞样细胞系RAW 264.7中抑制促炎诱导型一氧化氮合酶（iNOS）的蛋白表达。
