These authors contributed equally to the work..
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
Mar Drugs. 2011;9(10):2036-2045. doi: 10.3390/md9102036. Epub 2011 Oct 19.
Four new eunicellin-based diterpenoids, krempfielins A-D (1-4), along with two known compounds (5 and 6) have been isolated from a soft coral Cladiella krempfi. The structures of the new metabolites were elucidated by extensive spectroscopic analysis and by comparison with spectroscopic data of related known compounds. Compounds 5 and 6 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines. Furthermore, compounds 2, 3, 5 and 6 were shown to exert significant in vitro anti-inflammatory activity against LPS-stimulated RAW264.7 macrophage cells.
从软珊瑚 Cladiella krempfi 中分离得到了四个新的基于 eunicellin 的二萜类化合物，krempfielins A-D（1-4），以及两个已知化合物（5 和 6）。通过广泛的光谱分析，并与相关已知化合物的光谱数据进行比较，确定了新代谢产物的结构。结果表明，化合物 5 和 6 对一组有限的癌细胞系具有细胞毒性。此外，化合物 2、3、5 和 6 对 LPS 刺激的 RAW264.7 巨噬细胞表现出显著的体外抗炎活性。
