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基于负载三环内酯的磁性/等离子体纳米颗粒的磁脂质体用于联合癌症治疗

Magnetoliposomes Based on Magnetic/Plasmonic Nanoparticles Loaded with Tricyclic Lactones for Combined Cancer Therapy.

作者信息

Rio Irina S R, Rodrigues Ana Rita O, Rodrigues Juliana M, Queiroz Maria-João R P, Calhelha R C, Ferreira Isabel C F R, Almeida Bernardo G, Pires Ana, Pereira André M, Araújo João P, Castanheira Elisabete M S, Coutinho Paulo J G

机构信息

Centre of Physics of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.

Centre of Chemistry (CQUM), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.

出版信息

Pharmaceutics. 2021 Nov 10;13(11):1905. doi: 10.3390/pharmaceutics13111905.

DOI:10.3390/pharmaceutics13111905
PMID:34834322
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8625448/
Abstract

Liposome-like nanoarchitectures containing manganese ferrite nanoparticles covered or decorated with gold were developed for application in dual cancer therapy, combining chemotherapy and photothermia. The magnetic/plasmonic nanoparticles were characterized using XRD, UV/Visible absorption, HR-TEM, and SQUID, exhibiting superparamagnetic behavior at room temperature. The average size of the gold-decorated nanoparticles was 26.7 nm for MnFeO with 5-7 nm gold nanospheres. The average size of the core/shell nanoparticles was 28.8 nm for the magnetic core and around 4 nm for the gold shell. Two new potential antitumor fluorescent drugs, tricyclic lactones derivatives of thienopyridine, were loaded in these nanosystems with very high encapsulation efficiencies (higher than 98%). Assays in human tumor cell lines demonstrate that the nanocarriers do not release the antitumor compounds in the absence of irradiation. Moreover, the nanosystems do not cause any effect on the growth of primary (non-tumor) cells (with or without irradiation). The drug-loaded systems containing the core/shell magnetic/plasmonic nanoparticles efficiently inhibit the growth of tumor cells when irradiated with red light, making them suitable for a triggered release promoted by irradiation.

摘要

开发了一种类似脂质体的纳米结构，其包含覆盖或装饰有金的锰铁氧体纳米颗粒，用于结合化疗和光热疗法的双重癌症治疗。使用XRD、紫外/可见吸收、高分辨率透射电子显微镜（HR-TEM）和超导量子干涉仪（SQUID）对磁性/等离子体纳米颗粒进行了表征，结果表明其在室温下表现出超顺磁性行为。对于带有5-7纳米金纳米球的锰铁氧体（MnFeO），金装饰纳米颗粒的平均尺寸为26.7纳米。对于磁芯/壳纳米颗粒，磁芯的平均尺寸为28.8纳米，金壳的平均尺寸约为4纳米。两种新型潜在抗肿瘤荧光药物，噻吩并吡啶的三环内酯衍生物，以非常高的包封效率（高于98%）负载在这些纳米系统中。在人类肿瘤细胞系中的测定表明，在没有照射的情况下，纳米载体不会释放抗肿瘤化合物。此外，纳米系统对原代（非肿瘤）细胞的生长没有任何影响（无论有无照射）。当用红光照射时，含有磁芯/壳磁性/等离子体纳米颗粒的载药系统能有效抑制肿瘤细胞的生长，使其适用于由照射促进的触发释放。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dfc/8625448/23f4d206ed40/pharmaceutics-13-01905-g014.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dfc/8625448/cda9f72eaa59/pharmaceutics-13-01905-sch001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dfc/8625448/b46fa7188d2f/pharmaceutics-13-01905-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dfc/8625448/8e323620269c/pharmaceutics-13-01905-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dfc/8625448/2d285e122f6f/pharmaceutics-13-01905-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dfc/8625448/3785dc520b4d/pharmaceutics-13-01905-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dfc/8625448/b2cc4f0d1457/pharmaceutics-13-01905-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dfc/8625448/20c5bdbbd15e/pharmaceutics-13-01905-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dfc/8625448/e81758a5af08/pharmaceutics-13-01905-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dfc/8625448/23f4d206ed40/pharmaceutics-13-01905-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dfc/8625448/fcc514946f73/pharmaceutics-13-01905-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dfc/8625448/cda9f72eaa59/pharmaceutics-13-01905-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dfc/8625448/217458b53f87/pharmaceutics-13-01905-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dfc/8625448/6f5cb44435f7/pharmaceutics-13-01905-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dfc/8625448/c920c165d039/pharmaceutics-13-01905-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dfc/8625448/60f2d1a4c902/pharmaceutics-13-01905-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dfc/8625448/6898614e4425/pharmaceutics-13-01905-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dfc/8625448/b46fa7188d2f/pharmaceutics-13-01905-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dfc/8625448/8e323620269c/pharmaceutics-13-01905-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dfc/8625448/2d285e122f6f/pharmaceutics-13-01905-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dfc/8625448/3785dc520b4d/pharmaceutics-13-01905-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dfc/8625448/b2cc4f0d1457/pharmaceutics-13-01905-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dfc/8625448/20c5bdbbd15e/pharmaceutics-13-01905-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dfc/8625448/e81758a5af08/pharmaceutics-13-01905-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dfc/8625448/23f4d206ed40/pharmaceutics-13-01905-g014.jpg

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