Singh Sukhbir, Sharma Neelam, Behl Tapan, Sarkar Bidhan Chandra, Saha Hasi Rani, Garg Kanika, Singh Supriya Kamari, Arora Sandeep, Amran Md Shah, Abdellatif Ahmed A H, Bilgrami Anwar L, Ashraf Ghulam Md, Rahman Md Sohanur
Department of Pharmacology, Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India.
Department of Biochemistry, Primeasia University, 12- Kemal Ataturk Avenue, HBR Tower Banani C/A, Dhaka 1213, Bangladesh.
Pharmaceutics. 2021 Nov 22;13(11):1978. doi: 10.3390/pharmaceutics13111978.
Psoriasis is a chronic inflammatory autoimmune disorder that moderately affects social and interpersonal relationships. Conventional treatments for psoriasis have certain problems, such as poor drug penetration through the skin, hyper-pigmentation, and a burning sensation on normal and diseased skin. Colloidal drug delivery systems overcome the pitfalls of conventional approaches for psoriasis therapeutics and have improved patient safety parameters, compliance, and superior effectiveness. They also entail reduced toxicity. This comprehensive review's topics include the pathogenesis of psoriasis, causes and types of psoriasis, conventional treatment alternatives for psoriasis, the need for colloidal drug delivery systems, and recent studies in colloidal drug delivery systems for the treatment of psoriasis. This review briefly describes colloidal drug delivery approaches, such as emulsion systems-i.e., multiple emulsion, microemulsion, and nano-emulsion; vesicular systems-i.e., liposomes, ethosomes, noisomes, and transferosomes; and particulate systems-i.e., solid lipid nanoparticles, solid lipid microparticles, nano-structured lipid carriers, dendrimers, nanocrystals, polymeric nanoparticles, and gold nanoparticles. The review was compiled through an extensive search of the literature through the PubMed, Google Scholar, and ScienceDirect databases. A survey of literature revealed seven formulations based upon emulsion systems, six vesicular drug delivery systems, and fourteen particulate systems reported for antipsoriatic drugs. Based on the literature studies of colloidal approaches for psoriasis management carried out in recent years, it has been concluded that colloidal pharmaceutical formulations could be investigated broadly and have a broad scope for effective management of many skin disorders in the coming decades.
银屑病是一种慢性炎症性自身免疫性疾病，对社交和人际关系有一定程度的影响。银屑病的传统治疗方法存在一些问题，如药物经皮渗透性差、色素沉着过度以及正常皮肤和患病皮肤均有烧灼感。胶体给药系统克服了银屑病治疗传统方法的缺陷，改善了患者的安全参数、依从性，并具有更高的有效性。它们还能降低毒性。这篇综述的主题包括银屑病的发病机制、银屑病的病因和类型、银屑病的传统治疗选择、对胶体给药系统的需求以及近年来胶体给药系统治疗银屑病的研究。本综述简要描述了胶体给药方法，如乳剂系统（即多重乳剂、微乳剂和纳米乳剂）；囊泡系统（即脂质体、醇质体、泡囊体和传递体）；以及微粒系统（即固体脂质纳米粒、固体脂质微粒、纳米结构脂质载体、树枝状大分子、纳米晶体、聚合物纳米粒和金纳米粒）。本综述通过广泛检索PubMed、谷歌学术和ScienceDirect数据库中的文献进行编撰。文献调查显示，有七种基于乳剂系统的制剂、六种囊泡给药系统以及十四种用于抗银屑病药物的微粒系统。基于近年来对银屑病管理胶体方法的文献研究，得出结论：胶体药物制剂可进行广泛研究，在未来几十年对多种皮肤疾病的有效管理方面具有广阔前景。
