Rademacher Jan-Gerd, Tampe Björn, Korsten Peter
Department of Nephrology and Rheumatology, University Medical Center Göttingen, 37075 Göttingen, Germany.
Vaccines (Basel). 2021 Nov 11;9(11):1313. doi: 10.3390/vaccines9111313.
Sarcoidosis can present as an acute form or take a chronic course. One of the acute presentations is Löfgren's syndrome (LS), consisting of the symptom triad of bilateral hilar lymphadenopathy, erythema nodosum, and ankle periarthritis. In addition, there are occasional reports of sarcoid-like reactions following drug exposures. Nevertheless, reports of sarcoidosis or LS after vaccination have not been published. Here, we report two cases of LS in a temporal association with different vaccines against the new coronavirus SARS-CoV-2. One patient developed the first symptoms three days after the second vaccination (first vaccination ChadOx-1, Astra Zeneca; second vaccination CX-024414, Moderna); in the second patient, symptoms started 28 days after the first vaccination (ChadOx-1, Astra Zeneca). Both patients eventually required treatment with glucocorticoids. Both patients achieved clinical improvement with treatment. In conclusion, we report the first two cases of LS shortly after SARS-CoV-2 vaccination.
结节病可呈急性形式或呈慢性病程。急性表现之一是 Löfgren 综合征（LS），由双侧肺门淋巴结肿大、结节性红斑和踝关节周围关节炎三联征组成。此外，偶尔有药物暴露后出现类结节病反应的报道。然而，关于接种疫苗后发生结节病或 LS 的报道尚未发表。在此，我们报告两例与不同的新型冠状病毒 SARS-CoV-2 疫苗存在时间关联的 LS 病例。一名患者在第二次接种疫苗三天后出现首发症状（第一次接种牛津-1 号疫苗，阿斯利康；第二次接种 CX-024414，莫德纳）；第二名患者在第一次接种疫苗（牛津-1 号疫苗，阿斯利康）28 天后出现症状。两名患者最终均需要糖皮质激素治疗。两名患者经治疗后临床症状均有改善。总之，我们报告了两例在接种 SARS-CoV-2 疫苗后不久发生 LS 的病例。
