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用于水溶液中阿霉素高级电化学检测的石墨烯量子点和Cu(I)液晶

Graphene Quantum Dots and Cu(I) Liquid Crystal for Advanced Electrochemical Detection of Doxorubicine in Aqueous Solutions.

作者信息

Motoc Ilies Sorina, Schinteie Bianca, Pop Aniela, Negrea Sorina, Cretu Carmen, Szerb Elisabeta I, Manea Florica

机构信息

"Coriolan Drăgulescu" Institute of Chemistry, Romanian Academy, 24 Mihai Viteazu Bvd., 300223 Timisoara, Romania.

Department of Applied Chemistry and Engineering of Inorganic Compounds and Environment, Politehnica University of Timisoara, 2 Victoriei Square, 300006 Timisoara, Romania.

出版信息

Nanomaterials (Basel). 2021 Oct 21;11(11):2788. doi: 10.3390/nano11112788.

DOI:10.3390/nano11112788
PMID:34835559
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8625772/
Abstract

Two paste electrodes based on graphene quantum dots and carbon nanotubes (GRQD/CNT) and one modified with a homoleptic liquid crystalline Cu(I) based coordination complex (Cu/GRQD/CNT) were obtained and morphostructurally and electrochemically characterized in comparison with simple CNT electrode (CNT) for doxorubicine (DOX) detection in aqueous solutions. GRQD/CNT showed the best electroanalytical performance by differential pulse voltammetry technique (DPV). Moreover, applying a preconcentration step prior to detection stage, the lowest limit of detection (1 ng/L) and the highest sensitivity (216,105 µA/mg·L) in comparison with reported literature data were obtained. Cu/GRQD/CNT showed good results using multiple pulse amperometry technique (MPA) and a favorable shifting of the potential detection to mitigate potential interferences. Both GRQD-based paste electrodes have a great potential for practical utility in DOX determination in water at trace concentration levels, using GRQD/CNT with DPV and in pharmaceuticals formulations using Cu/GRQD/CNT with MPA.

摘要

制备了两种基于石墨烯量子点和碳纳米管的糊状电极（GRQD/CNT）以及一种用均配型液晶铜（I）基配位络合物修饰的电极（Cu/GRQD/CNT），并与简单的碳纳米管电极（CNT）进行了形态结构和电化学表征，用于检测水溶液中的阿霉素（DOX）。通过差分脉冲伏安法（DPV），GRQD/CNT表现出最佳的电分析性能。此外，在检测阶段之前进行预富集步骤，与已报道的文献数据相比，获得了最低检测限（1 ng/L）和最高灵敏度（216,105 µA/mg·L）。使用多脉冲安培法（MPA），Cu/GRQD/CNT显示出良好的结果，并且检测电位有良好的偏移，以减轻潜在干扰。两种基于GRQD的糊状电极在使用GRQD/CNT结合DPV测定水中痕量浓度水平的DOX以及使用Cu/GRQD/CNT结合MPA测定药物制剂中的DOX方面都具有很大的实际应用潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcb0/8625772/e8c37cea9140/nanomaterials-11-02788-g013.jpg
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