Lin Xiangwei, Shen Yajing, Wang Lidai
School of Biomedical Engineering, Shenzhen University, Shenzhen 518055, China.
Department of Biomedical Engineering, City University of Hong Kong, Hong Kong 999077, China.
Nanomaterials (Basel). 2021 Oct 28;11(11):2879. doi: 10.3390/nano11112879.
Hemostasis is vital to save lives, reducing risks of organ failure and hemorrhagic shock. Exploring novel hemostatic materials and precise monitoring of the hemostatic status is of great importance for efficient hemostasis. We present the development of chitosan-graphene oxide-based hemostatic composite and multi-scale photoacoustic evaluation of the hemostatic performance. The hemostatic sponge can quickly and efficiently absorb the blood with its porous cavity and specific surficial property. We inspect the hemostatic performance via an in vitro blood absorption test and in vivo mouse bleeding injury experiments. Results show that the synthesized hemostatic sponge can not only absorb plasma in blood fast with its interior porous structure but also stimulate the interfacial reaction with erythrocytes and platelets. The superiority of multi-scale photoacoustic imaging for guiding, monitoring, and evaluating the hemostatic stages of sponges is demonstrated with high spatial resolution and great sensitivity at depths. Photoacoustic evaluation of a chitosan-graphene oxide-based hemostatic sponge has the potential to be transferred toward the clinical assessment of wound healing.
止血对于挽救生命、降低器官衰竭和失血性休克的风险至关重要。探索新型止血材料并精确监测止血状态对于实现高效止血具有重要意义。我们展示了基于壳聚糖-氧化石墨烯的止血复合材料的研发以及对止血性能的多尺度光声评估。该止血海绵凭借其多孔腔和特定的表面特性能够快速有效地吸收血液。我们通过体外血液吸收试验和体内小鼠出血损伤实验来检测止血性能。结果表明，合成的止血海绵不仅能够凭借其内部多孔结构快速吸收血液中的血浆，还能刺激与红细胞和血小板的界面反应。多尺度光声成像在引导、监测和评估海绵止血阶段方面的优势通过高空间分辨率和深部高灵敏度得以体现。基于壳聚糖-氧化石墨烯的止血海绵的光声评估具有向伤口愈合临床评估转化的潜力。
