Leonardi Antonio Alessio, Lo Faro Maria José, Fazio Barbara, Spinella Corrado, Conoci Sabrina, Livreri Patrizia, Irrera Alessia
Dipartimento di Fisica e Astronomia "Ettore Majorana", Università degli Studi di Catania, Via S. Sofia 64, 95123 Catania, Italy.
Istituto per i Processi Chimico-Fisici, Consiglio Nazionale delle Ricerche (CNR-IPCF), Viale F. Stagno D'Alcontres 37, 98158 Messina, Italy.
Nanomaterials (Basel). 2021 Nov 5;11(11):2970. doi: 10.3390/nano11112970.
Nanostructures are arising as novel biosensing platforms promising to surpass current performance in terms of sensitivity, selectivity, and affordability of standard approaches. However, for several nanosensors, the material and synthesis used make the industrial transfer of such technologies complex. Silicon nanowires (NWs) are compatible with Si-based flat architecture fabrication and arise as a hopeful solution to couple their interesting physical properties and surface-to-volume ratio to an easy commercial transfer. Among all the transduction methods, fluorescent probes and sensors emerge as some of the most used approaches thanks to their easy data interpretation, measure affordability, and real-time in situ analysis. In fluorescent sensors, Si NWs are employed as substrate and coupled with several fluorophores, NWs can be used as quenchers in stem-loop configuration, and have recently been used for direct fluorescent sensing. In this review, an overview on fluorescent sensors based on Si NWs is presented, analyzing the literature of the field and highlighting the advantages and drawbacks for each strategy.
纳米结构作为新型生物传感平台正在兴起，有望在灵敏度、选择性和标准方法的可承受性方面超越当前性能。然而，对于几种纳米传感器而言，所使用的材料和合成方法使得此类技术的工业转化变得复杂。硅纳米线（NWs）与基于硅的平面架构制造兼容，有望成为将其有趣的物理特性和表面积与体积之比与简便的商业转化相结合的解决方案。在所有的传感方法中，荧光探针和传感器因其易于数据解读、测量成本低以及实时原位分析等优点，成为最常用的方法之一。在荧光传感器中，硅纳米线被用作底物，并与多种荧光团结合，纳米线可在茎环结构中用作猝灭剂，且最近已被用于直接荧光传感。在本综述中，对基于硅纳米线的荧光传感器进行了概述，分析了该领域的文献，并突出了每种策略的优缺点。
