Vijay Renjini, Mendhi Jayanti, Prasad Karthika, Xiao Yin, MacLeod Jennifer, Ostrikov Kostya Ken, Zhou Yinghong
School of Mechanical, Medical and Process Engineering, Faculty of Engineering, Queensland University of Technology (QUT), Brisbane, QLD 4000, Australia.
Centre for Biomedical Technologies, Queensland University of Technology (QUT), Brisbane, QLD 4000, Australia.
Nanomaterials (Basel). 2021 Nov 5;11(11):2977. doi: 10.3390/nano11112977.
Dental implants are used broadly in dental clinics as the most natural-looking restoration option for replacing missing or highly diseased teeth. However, dental implant failure is a crucial issue for diabetic patients in need of dentition restoration, particularly when a lack of osseointegration and immunoregulatory incompetency occur during the healing phase, resulting in infection and fibrous encapsulation. Bio-inspired or biomimetic materials, which can mimic the characteristics of natural elements, are being investigated for use in the implant industry. This review discusses different biomimetic dental implants in terms of structural changes that enable antibacterial properties, drug delivery, immunomodulation, and osseointegration. We subsequently summarize the modification of dental implants for diabetes patients utilizing carbon nanomaterials, which have been recently found to improve the characteristics of biomimetic dental implants, including through antibacterial and anti-inflammatory capabilities, and by offering drug delivery properties that are essential for the success of dental implants.
牙种植体在牙科诊所中被广泛应用,是替代缺失或严重病变牙齿的最自然美观的修复选择。然而,牙种植体失败对于需要牙列修复的糖尿病患者来说是一个关键问题,尤其是在愈合阶段出现骨结合不足和免疫调节功能不全时,会导致感染和纤维包裹。受生物启发或仿生的材料,能够模仿天然元素的特性,正在被研究用于植入行业。本文综述了不同的仿生牙种植体在结构变化方面的情况,这些变化使其具有抗菌性能、药物递送、免疫调节和骨结合能力。随后,我们总结了利用碳纳米材料对糖尿病患者牙种植体的改性,最近发现碳纳米材料可以改善仿生牙种植体的特性,包括通过抗菌和抗炎能力,以及提供对牙种植体成功至关重要的药物递送特性。