Chue-Gonçalves Marcelly, Pereira Giovana N, Faccin-Galhardi Lígia C, Kobayashi Renata K T, Nakazato Gerson
Laboratory of Basic and Applied Bacteriology, Department of Microbiology, Biological Sciences Center, Londrina State University, Londrina 86057-970, Brazil.
Laboratory of Virology, Department of Microbiology, Biological Sciences Center, Londrina State University, Londrina 86057-970, Brazil.
Nanomaterials (Basel). 2021 Nov 19;11(11):3118. doi: 10.3390/nano11113118.
In view of the current Coronavirus Disease 2019 (COVID-19) pandemic outbreak, the research community is focusing on development of diagnostics, treatment, and vaccines to halt or reverse this scenario. Although there are already various vaccines available, adaptive mutations in the SARS-CoV-2 genome can alter its pathogenic potential and, at the same time, increase the difficulty of developing drugs or immunization by vaccines. Nanotechnology carries a potential to act in all stages in fighting this viral disease, with several possibilities of strategies such as applying nanoparticles directly as antivirals in delivery systems against these viruses or incorporating them in materials, with power of achievement in therapeutics, vaccines and prevention. In this paper, we review and bring insights of recent studies using metal nanocomposites as antivirals against coronavirus and structurally similar viruses.
鉴于当前2019冠状病毒病（COVID-19）大流行爆发，研究界正专注于开发诊断方法、治疗方法和疫苗，以阻止或扭转这种局面。尽管已经有多种疫苗可用，但严重急性呼吸综合征冠状病毒2（SARS-CoV-2）基因组中的适应性突变会改变其致病潜力，同时增加开发药物或疫苗免疫的难度。纳米技术在对抗这种病毒性疾病的各个阶段都具有发挥作用的潜力，有多种策略可能性，例如将纳米颗粒直接用作针对这些病毒的递送系统中的抗病毒剂，或将它们纳入材料中，在治疗、疫苗和预防方面都有取得成果的能力。在本文中，我们回顾并介绍了最近使用金属纳米复合材料作为抗冠状病毒和结构相似病毒的抗病毒剂的研究见解。
