Bagwe-Parab Siddhi, Yadav Pratik, Kaur Ginpreet, Tuli Hardeep Singh, Buttar Harpal Singh
Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, Shri Vile Parle Kelavani Mandals Narsee Monjee Institute of Management Studies, Mumbai, India.
Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, India.
Front Pharmacol. 2020 Sep 11;11:01100. doi: 10.3389/fphar.2020.01100. eCollection 2020.
The incidence of gastrointestinal disorders (GID) and cancers is escalating all over the world. Limited consumption of colostrum by newborns not only weakens the immune system but also predisposes infants to microbial infections. Colostrum is nature's perfect food, sometimes referred to as the 'elixir of life'. Breast-fed infants have a lower incidence of GI tract infections than infants fed formula or cow's milk. As per WHO statistics, cancer is the most prevalent disease globally and causes 9.6 million deaths worldwide. The current strategies for treating cancer include chemotherapy, radiation, and surgery. However, chemotherapy and radiation exposure are usually associated with serious long-term side effects and deterioration in the quality of life (QOL) of patients. Furthermore, the hospitalization and medication costs for treating cancers are exorbitant and impose high economic burden on healthcare systems. People are desperately looking for cost-effective and affordable alternative therapies for treating GID and cancers. Therefore, there is an urgent need for clinically evaluating the anticancer compounds isolated from plants and animals. Such therapies would not only be economical and have fewer side effects, but also help to improve the QOL of cancer patients. Recently, bovine colostrum (BC) has caught the attention of many investigators to explore its anticancer potential in humans. BC impregnated dressings are highly effective in treating chronic wounds and diabetic foot ulcer. BC is rich in lactoferrin, a glycoprotein with strong antioxidant, anti-inflammatory, anti-cancer, and anti-microbial properties. Intravaginal application of BC tablets is effective in causing the regression of low-grade cervical intraepithelial neoplasia. The underlying mechanisms of BC at cellular, genetic, and molecular levels remain to be ascertained. Oral BC supplement is well-tolerated, but some people may experience problems such as flatulence and nausea. Well-designed, randomized, placebo-controlled, clinical trials are needed to access the therapeutic potential, long-term safety, and optimal doses of BC products. This review is aimed to highlight the anticancer potential of BC and its components, and the therapeutic applications of BC supplements in treating gastrointestinal diseases in children and adults. We also discuss the health promotion benefits and therapeutic potential of BC nutraceuticals in reducing the incidence of non-communicable diseases.
全球范围内，胃肠道疾病（GID）和癌症的发病率正在不断上升。新生儿初乳摄入量有限不仅会削弱免疫系统，还会使婴儿易受微生物感染。初乳是大自然的完美食物，有时被称为“生命的灵丹妙药”。母乳喂养的婴儿患胃肠道感染的几率低于配方奶或牛奶喂养的婴儿。根据世界卫生组织的统计数据，癌症是全球最普遍的疾病，在全球导致960万人死亡。目前治疗癌症的策略包括化疗、放疗和手术。然而，化疗和放疗通常会带来严重的长期副作用，并导致患者生活质量（QOL）下降。此外，癌症治疗的住院和用药费用高昂，给医疗系统带来了沉重的经济负担。人们迫切需要寻找经济有效且负担得起的GID和癌症替代疗法。因此，迫切需要对从植物和动物中分离出的抗癌化合物进行临床评估。这样的疗法不仅经济且副作用较少，还有助于提高癌症患者的生活质量。最近，牛初乳（BC）引起了许多研究人员的关注，他们探索其对人类的抗癌潜力。BC浸渍敷料在治疗慢性伤口和糖尿病足溃疡方面非常有效。BC富含乳铁蛋白，这是一种具有强大抗氧化、抗炎、抗癌和抗菌特性的糖蛋白。阴道内应用BC片剂可有效使低度宫颈上皮内瘤变消退。BC在细胞、基因和分子水平上的潜在机制仍有待确定。口服BC补充剂耐受性良好，但有些人可能会出现肠胃胀气和恶心等问题。需要精心设计、随机、安慰剂对照的临床试验来评估BC产品的治疗潜力、长期安全性和最佳剂量。本综述旨在强调BC及其成分的抗癌潜力，以及BC补充剂在治疗儿童和成人胃肠道疾病中的治疗应用。我们还讨论了BC营养保健品在降低非传染性疾病发病率方面的健康促进益处和治疗潜力。
