Department of Otorhinolaryngology-Head & Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam 13496, Korea.
Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Korea.
Nutrients. 2021 Nov 2;13(11):3927. doi: 10.3390/nu13113927.
Although the effects of coffee consumption and physical exercise on the risk of cancer have been suggested, their interactions have not been investigated. The present cross-sectional study aimed to investigate the correlation of coffee consumption and physical exercise with cancer. Participants ≥40 years old in the Korean Genome and Epidemiology Study 2004-2016 were included ( = 162,220). Histories of gastric cancer, hepatic cancer, colon cancer, breast cancer, uterine cervix cancer, lung cancer, thyroid cancer, prostate cancer, and bladder cancer were analyzed according to the coffee consumption groups using logistic regression models. The odds among individuals in the >60 cups/month coffee group were lower for gastric cancer (adjusted odds ratio (aOR) = 0.80 (95% confidence intervals = 0.65-0.98)), hepatic cancer (0.32 (0.18-0.58)), colon cancer (0.53 (0.39-0.72)), breast cancer (0.56 (0.45-0.70)), and thyroid cancer (0.71 (0.59-0.85)) than for individuals in the no coffee group. Physical exercise of ≥150 min/week was correlated with higher odds for gastric cancer (1.18 (1.03-1.36)), colon cancer (1.52 (1.26-1.83)), breast cancer (1.53 (1.35-1.74)), thyroid cancer (1.42 (1.27-1.59)), and prostate cancer (1.61 (1.13-2.28)) compared to no exercise. Coffee consumption and physical exercise showed an interaction in thyroid cancer ( = 0.002). Coffee consumption was related to a decreased risk of gastric cancer, hepatic cancer, colon cancer, breast cancer, and thyroid cancer in the adult population. Physical exercise was positively correlated with gastric cancer, colon cancer, breast cancer, thyroid cancer, and prostate cancer.
尽管已经提出了咖啡消费和体育锻炼对癌症风险的影响，但它们之间的相互作用尚未得到研究。本横断面研究旨在调查咖啡消费和体育锻炼与癌症的相关性。纳入了 2004-2016 年韩国基因组和流行病学研究中≥40 岁的参与者（n=162220）。根据咖啡消费组，使用逻辑回归模型分析了胃癌、肝癌、结肠癌、乳腺癌、子宫颈癌、肺癌、甲状腺癌、前列腺癌和膀胱癌的病史。与不喝咖啡组相比，>60 杯/月咖啡组的个体患胃癌（调整后的优势比[aOR]=0.80（95%置信区间[CI]=0.65-0.98））、肝癌（0.32（0.18-0.58））、结肠癌（0.53（0.39-0.72））、乳腺癌（0.56（0.45-0.70））和甲状腺癌（0.71（0.59-0.85））的几率较低。每周运动≥150 分钟与胃癌（1.18（1.03-1.36））、结肠癌（1.52（1.26-1.83））、乳腺癌（1.53（1.35-1.74））、甲状腺癌（1.42（1.27-1.59））和前列腺癌（1.61（1.13-2.28））的几率较高相关。与不运动相比，咖啡消费和体育锻炼在甲状腺癌中存在交互作用（=0.002）。在成年人群中，咖啡消费与胃癌、肝癌、结肠癌、乳腺癌和甲状腺癌的风险降低相关。体育锻炼与胃癌、结肠癌、乳腺癌、甲状腺癌和前列腺癌呈正相关。
