Department of Physiology, School of Pharmacy, University of Granada, Campus de Cartuja s/n, 18071 Granada, Spain.
Institute of Nutrition and Food Technology "José Mataix", Center of Biomedical Research, University of Granada, Avda. del Conocimiento s/n, 18016 Granada, Spain.
Nutrients. 2021 Nov 10;13(11):3999. doi: 10.3390/nu13113999.
Physical activity, exercise, or physical fitness are being studied as helpful nonpharmacological therapies to reduce signaling pathways related to inflammation. Studies describing changes in intestinal microbiota have stated that physical activity could increase the microbial variance and enhance the ratio of Firmicutes/Bacteroidetes, and both actions could neutralize the obesity progression and diminish body weight. The aim of this review is to provide an overview of the literature describing the relationship between physical activity profiles and gut microbiota and in obesity and some associated comorbidities. Promoting physical activity could support as a treatment to maintain the gut microbiota composition or to restore the balance toward an improvement of dysbiosis in obesity; however, these mechanisms need to be studied in more detail. The opportunity to control the microbiota by physical activity to improve health results and decrease obesity and related comorbidities is very attractive. Nevertheless, several incompletely answered questions need to be addressed before this strategy can be implemented.
身体活动、锻炼或身体健身正被研究为有助于减少与炎症相关信号通路的非药物治疗方法。描述肠道微生物组变化的研究表明，身体活动可以增加微生物的变异性，并提高厚壁菌门/拟杆菌门的比例，这两个作用都可以中和肥胖的进展并减轻体重。本综述的目的是提供一个概述，描述身体活动模式与肠道微生物群在肥胖及其一些相关合并症中的关系。促进身体活动可以作为一种治疗方法来维持肠道微生物群的组成，或恢复平衡，改善肥胖中的肠道微生态失调；然而，这些机制需要更详细地研究。通过身体活动控制微生物群来改善健康结果并减少肥胖和相关合并症的机会非常有吸引力。然而，在实施这种策略之前，需要解决几个尚未完全回答的问题。
