Laboratory of Epidemiology and Biostatistics, National Gastroenterology Institute, "S. de Bellis" Research Hospital, Via Turi 27, 70013 Castellana Grotte, Bari, Italy.
Human Nutrition Research Center (CenINH), School of Nutrition, Faculty of Medical Sciences, Universidad Nacional de Córdoba, Córdoba X5000, Argentina.
Nutrients. 2021 Nov 10;13(11):4002. doi: 10.3390/nu13114002.
In real life, nutrition goes beyond purely biological domains. Primary prevention is the most efficient approach for reducing the risk of mortality. We aimed to study the association of lifestyle, as measured by a modified World Cancer Research Fund/American Institute for Cancer Research (mWCRF/AICR) scoring system with all-cause, digestive system disease-related (DSD-related), cardiovascular disease-related (CVD-related), cancer-related and other cause-related mortality using data from two population-based cohort studies conducted in Southern Italy.
A random sample of 5271 subjects aged 18 years or older was enrolled in 2005-2006 and followed up until 2020. Usual food intakes were estimated using a validated dietary questionnaire. Competing risks survival models were applied.
High adherence to the mWCRF/AICR score was found to be statistically significant and negatively associated with all-cause mortality (HR 0.56, 95%CI 0.39; 0.82), DSD-related mortality (SHR 0.38, 95%CI 0.15; 0.97) and cancer-related mortality (SHR 0.43, 95%CI 0.19; 0.97) in the male sub-cohort and other-cause mortality (SHR 0.43, 95%CI 0.21; 0.88) only in the female group.
This mWCRF/AICR score can be seen as a simple, easy tool for use in clinical practice to evaluate both qualitative and quantitative aspects of the diet.
在现实生活中，营养不仅限于纯粹的生物学领域。一级预防是降低死亡率风险的最有效方法。我们旨在研究生活方式与全因死亡率、消化系统疾病相关死亡率、心血管疾病相关死亡率、癌症相关死亡率和其他原因相关死亡率之间的关联，生活方式通过一个改良的世界癌症研究基金会/美国癌症研究所（mWCRF/AICR）评分系统进行衡量，使用来自意大利南部进行的两项基于人群的队列研究的数据。
2005-2006 年招募了 5271 名年龄在 18 岁或以上的随机样本，并随访至 2020 年。使用经过验证的饮食问卷估计习惯性食物摄入量。应用竞争风险生存模型。
高依从性与全因死亡率（HR 0.56，95%CI 0.39；0.82）、消化系统疾病相关死亡率（SHR 0.38，95%CI 0.15；0.97）和癌症相关死亡率（SHR 0.43，95%CI 0.19；0.97）呈统计学显著负相关，男性亚组中与癌症相关死亡率（SHR 0.43，95%CI 0.19；0.97）呈统计学显著负相关，女性组中与其他原因死亡率（SHR 0.43，95%CI 0.21；0.88）呈统计学显著负相关。
这个 mWCRF/AICR 评分可以被视为一种简单易用的工具，可用于临床实践中评估饮食的定性和定量方面。
