Ibarz-Barberá Marta, Morales-Fernández Laura, Corroto-Cuadrado Arturo, Martinez-Galdón Fátima, Tañá-Rivero Pedro, Gómez de Liaño Rosario, Teus Miguel A
Grupo Oftalvist, Juan Bravo Street #1, 28006, Madrid, Spain.
Hospital Moncloa, HLA Hospitales, Madrid, Spain.
Ophthalmol Ther. 2022 Feb;11(1):293-310. doi: 10.1007/s40123-021-00428-0. Epub 2021 Nov 26.
To analyze the effects of PRESERFLO on corneal endothelial cell density (ECD).
Forty-six eyes that underwent PRESERFLO implantation were followed up for 12 months. Specular microscopy was performed preoperatively and at 1, 3, 6, and 12 months postoperatively to measure central ECD and mean monthly reduction (MMR). Anterior segment optical coherence tomography (AS-OCT) was applied to measure the tube-endothelium (TE < 200 μm, 201-500 μm, > 500 μm) distance. The relationship between TE distance and ECD was analyzed with a linear mixed-effects model.
Central ECD decreased significantly at 1 year (7.4%, p = 0.04), with an MMR of -15 ± 25 cells/mm. Regarding TE distance groups, there was an 18% ECD reduction in the < 200 μm group vs. 1% in the > 500 μm group (p = 0.08). Endothelial cell loss was related to TE distance (mean 482.9 ± 238 μm), with a higher rate at 1 month in comparison to 12 months for the same tube position in the anterior chamber (-174.8 ± 65.2 cells/mm at 1 month vs. 30.2 ± 11.3 cells/mm at 12 months, p < 0.01). From month 6, tubes located > 600 μm from the endothelium showed EC loss close to zero.
The PRESERFLO implant is associated with a loss of EC from the immediate postoperative period that continues over time at lower rates. A shorter TE distance appears to cause more severe ECD loss.
分析 PRESERFLO 对角膜内皮细胞密度（ECD）的影响。
对 46 只接受 PRESERFLO 植入术的眼睛进行了 12 个月的随访。术前以及术后 1、3、6 和 12 个月进行镜面显微镜检查，以测量中央 ECD 和平均每月降低值（MMR）。应用眼前节光学相干断层扫描（AS-OCT）测量管-内皮（TE＜200μm、201 - 500μm、＞500μm）距离。使用线性混合效应模型分析 TE 距离与 ECD 之间的关系。
1 年时中央 ECD 显著下降（7.4%，p = 0.04），MMR 为 -15±25 个细胞/mm²。关于 TE 距离组，＜200μm 组的 ECD 降低了 18%，而＞500μm 组为 1%（p = 0.08）。内皮细胞丢失与 TE 距离有关（平均 482.9±238μm），在前房相同管位置，1 个月时的丢失率高于 12 个月时（1 个月时为 -174.8±65.2 个细胞/mm²，12 个月时为 30.2±11.3 个细胞/mm²，p＜0.01）。从第 6 个月起，距离内皮＞600μm 的管显示内皮细胞丢失接近零。
PRESERFLO 植入物与术后即刻开始的内皮细胞丢失有关，且随着时间推移以较低速率持续。较短的 TE 距离似乎会导致更严重的 ECD 丢失。
