Marinho Paula M, Marcos Alléxya A A, Branco Ana M C, Mourad Walid M, Sakamoto Victoria, Romano Andre C, Farah Michel, Rosen Richard B, Schor Paulo, Abraao Paulo, Nascimento Heloisa, Belfort Rubens
São Paulo Hospital, Paulista School of Medicine, Federal University of São Paulo, Rua Botucatu 816 Vila Clementino, São Paulo, Brazil.
Vision Institute - IPEPO, São Paulo, Brazil.
Int J Retina Vitreous. 2021 Nov 27;7(1):71. doi: 10.1186/s40942-021-00341-5.
The main purpose of this study was to investigate the presence of retinal autofluorescence findings in COVID-19 patients. Observational study conducted in São Paulo in 2020. Demographic, medical history, and concomitant events, as well as medications used, hospitalization details, and laboratory test results, were obtained. Patients underwent eye examination and multimodal imaging, including color, red-free, autofluorescence fundus photography and optical coherence tomography. Eighteen patients had autofluorescence findings (6 females; average age 54 years, range 31 to 86 years; 26 eyes). Hyper-autofluorescence findings were present in 6 patients, Hypo-autofluorescence in 14 patients, and 6 patients had mixed pattern lesions. Retinal autofluorescence abnormalities were present in COVID-19 patients and may be secondary to primary or secondary changes caused by the SARS-CoV-2.
本研究的主要目的是调查新冠病毒肺炎（COVID-19）患者中视网膜自发荧光的表现。2020年在圣保罗进行了一项观察性研究。收集了患者的人口统计学信息、病史、伴随事件、用药情况、住院详情及实验室检查结果。患者接受了眼科检查和多模态成像，包括彩色、无赤光、自发荧光眼底照相及光学相干断层扫描。18例患者有自发荧光表现（6例女性；平均年龄54岁，范围31至86岁；26只眼）。6例患者出现高自发荧光表现，14例患者出现低自发荧光表现，6例患者有混合性病变。COVID-19患者存在视网膜自发荧光异常，可能继发于严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的原发性或继发性改变。
