Department of Chemical Engineering, School of Engineering, Thammasat University, Pathumthani, 12120, Thailand.
Department of Chemical Engineering, School of Engineering, Thammasat University, Pathumthani, 12120, Thailand; Center of Clinical Engineering, School of Engineering, Thammasat University, Pathumthani, 12120, Thailand.
J Pharm Sci. 2022 Jun;111(6):1690-1699. doi: 10.1016/j.xphs.2021.11.015. Epub 2021 Nov 25.
The purpose of this study was to investigate in vitro drug release kinetics and to develop diffusion model of curcumin loaded Pluronic F127/Oleic acid(OA)-FeO nanoparticles. The prepared superparamagnetic nanoparticles by co-precipitation technique were characterized by the average size, size distribution, crystallinity, colloidal stability and magnetic property. The release of curcumin was triggered by an acidic environment in pH 5.0 of phosphate buffer saline. Release data of various curcumin loading (15, 25 and 30 ppm) were fitted using non-linear first-order, second-order, Higuchi and Korsmeyer-Peppas model. All the curcumin release mechanism followed Korsmeyer-Peppas model with n values less than 0.45 indicating the Fickian diffusion of curcumin from the prepared nanomicelles. The dynamic of controlled drug release of dilute curcumin loading was well described by a combination of diffusion and first-order release rate. The corresponding diffusion coefficient and kinetic rate were 9.1 × 10 cm⋅min and 6.51 × 10 min, which were used as controlled release to achieve the desired curcumin constant release rate in the delivery system.
本研究旨在研究姜黄素载药 Pluronic F127/Oleic acid(OA)-FeO 纳米粒子的体外药物释放动力学并建立扩散模型。采用共沉淀法制备超顺磁性纳米粒子，通过平均粒径、粒径分布、结晶度、胶体稳定性和磁性能进行表征。在 pH 5.0 的磷酸盐缓冲盐溶液的酸性环境下触发姜黄素的释放。通过非线性一阶、二阶、Higuchi 和 Korsmeyer-Peppas 模型拟合各种姜黄素载药量（15、25 和 30 ppm）的释放数据。所有姜黄素释放机制均符合 Korsmeyer-Peppas 模型，n 值小于 0.45，表明姜黄素从制备的纳米胶束中呈菲克扩散。用扩散和一级释放速率的组合可以很好地描述低浓度姜黄素载药量的药物控制释放动力学。相应的扩散系数和动力学速率分别为 9.1×10 cm·min 和 6.51×10 min，可作为控制释放，在输送系统中实现所需的姜黄素恒速释放。
