Murnan Aaron W, Keim Sarah A, Yeates Keith Owen, Boone Kelly M, Sheppard Kelly W, Klebanoff Mark A
Center for Biobehavioral Health, The Abigail Wexner Research Institute at Nationwide Children's Hospital, 700 Childrens Drive, Columbus, Ohio, USA, 43215.
Department of Pediatrics, The Ohio State University College of Medicine, 370 W. 9 Avenue, Columbus, Ohio, USA, 43210.
J Appl Dev Psychol. 2021 Nov-Dec;77. doi: 10.1016/j.appdev.2021.101348. Epub 2021 Oct 28.
Prenatal marijuana exposure (PME) negatively impacts child development and behavior; however, few studies have examined these associations at early ages among children exposed to today's highly potent marijuana. Using a prospective prenatal cohort (Columbus, Ohio, USA), PME was determined from maternal self-report, medical chart abstraction, and urine toxicology from prenatal visits and delivery. At age 3.5 years, 63 offspring children completed tasks assessing executive function (EF), visual spatial ability, emotion regulation, and aggressive behavior. Caregivers reported on children's EF and problem behaviors. Logistic regressions and analyses of covariance controlling for key variables were used to examine associations between PME and child outcomes. Compared to non-exposed children, children with PME had more sleep-related problems, withdrawal symptoms, and externalizing problems, including aggressive behaviors and oppositional defiant behaviors. Children with and without PME did not differ in terms of executive functioning. Findings suggest behavioral problems associated with PME may manifest by age 3.5.
产前接触大麻（PME）会对儿童发育和行为产生负面影响；然而，很少有研究在接触当今高浓度大麻的儿童早期阶段考察这些关联。利用一个前瞻性产前队列（美国俄亥俄州哥伦布市），通过产妇自我报告、病历摘要以及产前检查和分娩时的尿液毒理学检测来确定PME。在3.5岁时，63名后代儿童完成了评估执行功能（EF）、视觉空间能力、情绪调节和攻击行为的任务。照顾者报告了儿童的EF和问题行为。使用逻辑回归和对关键变量进行控制的协方差分析来考察PME与儿童结局之间的关联。与未接触大麻的儿童相比，接触PME的儿童有更多与睡眠相关的问题、戒断症状以及外化问题，包括攻击行为和对立违抗行为。接触和未接触PME的儿童在执行功能方面没有差异。研究结果表明，与PME相关的行为问题可能在3.5岁时就会显现。
