Azzouz Safaa, Lanoue Derek, Champagne Katéri, Genest Genevieve
Division of Internal Medicine, McGill University Health Centre, Montréal, Québec, Canada.
Division of Allergy and Immunology, McGill University Health Centre, Montréal, Québec, Canada.
Allergy Asthma Clin Immunol. 2023 Apr 20;19(1):31. doi: 10.1186/s13223-023-00788-1.
With ongoing COVID-19 vaccination schedules and the popularity of cosmetic fillers, it is important to examine and record associated adverse reactions to a more general audience of health care professionals. Case reports exist in subspecialty journals outlining reactions after SARS-CoV-2 infection and vaccination. This is one of the first cases published in Canada, and it highlights priorities and challenges faced by physicians in assessing and managing patients presenting with adverse reactions post vaccination.
We present a case of a 43 -year-old women with delayed type 4 hypersensitivity reaction to hyaluronic acid cosmetic filler triggered by COVID-19 mRNA vaccination. We outline the clinical presentation, diagnosis, complications, and treatment of a late inflammatory reaction to hyaluronic acid filler and highlight the treatment priorities for clinicians faced with similar presentations.
The differential diagnosis of delayed onset nodules formation post filler injection is broad and includes redistribution of fillers, inflammatory reaction to biofilm, and delayed hypersensitivity reaction. As result, in order to make the right diagnosis, administer the appropriate treatment and achieve great cosmetic results, we highly recommend seeking expert opinion from dermatologist, plastic surgeon and allergist immunologist in a timely manner.
随着新冠疫苗接种计划的持续推进以及美容填充剂的广泛使用，向更广大的医疗保健专业人员群体检查和记录相关不良反应非常重要。专科期刊上有病例报告概述了感染新型冠状病毒2后及接种疫苗后的反应。这是加拿大发表的首批病例之一，它突出了医生在评估和管理接种疫苗后出现不良反应的患者时所面临的重点问题和挑战。
我们报告一例43岁女性，其对透明质酸美容填充剂的迟发型4型超敏反应由新冠信使核糖核酸疫苗引发。我们概述了透明质酸填充剂迟发性炎症反应的临床表现、诊断、并发症及治疗，并强调了面对类似情况的临床医生的治疗重点。
填充剂注射后迟发性结节形成的鉴别诊断范围广泛，包括填充剂的重新分布、对生物膜的炎症反应以及迟发性超敏反应。因此，为了做出正确诊断、给予恰当治疗并取得良好的美容效果，我们强烈建议及时寻求皮肤科医生、整形外科医生和过敏免疫科医生的专家意见。
