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日本公众对源自人诱导多能干细胞的配子的创造和使用的态度。

Public attitudes in Japan toward the creation and use of gametes derived from human-induced pluripotent stem cells.

作者信息

Sawai Tsutomu, Hatta Taichi, Akatsuka Kyoko, Fujita Misao

机构信息

Institute for the Advanced Study of Human Biology (WPI-ASHBi), KUIAS Kyoto University, Japan, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.

Shizuoka Graduate University of Public Health, Japan, 4-27-2 Kita Ando, Aoi-ku, Shizuoka, 420-0881, Japan.

出版信息

Future Sci OA. 2021 Oct 22;7(10):FSO755. doi: 10.2144/fsoa-2021-0066. eCollection 2021 Dec.

DOI:10.2144/fsoa-2021-0066
PMID:34840812
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8610011/
Abstract

AIM

To ascertain to what extent the Japanese general public accept the creation and use of derived (IVD)-gametes derived from human-induced pluripotent stem cells.

MATERIALS & METHODS: We conducted an online survey and obtained answers from 3096 respondents.

RESULTS

78.6% of the respondents answered that they would accept the creation and use of IVD-gametes for research purposes, 51.7% answered that they would accept the creation and use of embryos with IVD-gametes for research purposes, and 25.9% answered that they would accept childbirth using embryos with IVD-gametes.

DISCUSSION

The results that approximately half of the respondents answered that they would accept the creation of embryos with IVD-gametes, which has not been allowed in the current Japanese research guidelines, is astonishing.

摘要

目的

确定日本普通民众在多大程度上接受源自人诱导多能干细胞的体外衍生（IVD）配子的创建和使用。

材料与方法

我们进行了一项在线调查，获得了3096名受访者的回答。

结果

78.6%的受访者表示他们会接受为研究目的创建和使用IVD配子，51.7%的受访者表示他们会接受为研究目的创建和使用含有IVD配子的胚胎，25.9%的受访者表示他们会接受使用含有IVD配子的胚胎分娩。

讨论

约一半的受访者表示他们会接受创建含有IVD配子的胚胎，而这在当前日本的研究指导方针中是不被允许的，这一结果令人惊讶。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c54e/8610011/e9014cd2d25d/fsoa-07-755-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c54e/8610011/04f72c6afd50/fsoa-07-755-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c54e/8610011/79e53aaf1271/fsoa-07-755-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c54e/8610011/fbb17f37598f/fsoa-07-755-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c54e/8610011/e9014cd2d25d/fsoa-07-755-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c54e/8610011/04f72c6afd50/fsoa-07-755-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c54e/8610011/79e53aaf1271/fsoa-07-755-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c54e/8610011/fbb17f37598f/fsoa-07-755-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c54e/8610011/e9014cd2d25d/fsoa-07-755-g4.jpg

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本文引用的文献

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Generation of human oogonia from induced pluripotent stem cells in vitro.体外诱导多能干细胞生成人类卵原细胞。
Science. 2018 Oct 19;362(6412):356-360. doi: 10.1126/science.aat1674. Epub 2018 Sep 20.
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Promoting In Vitro Gametogenesis Research with a Social Understanding.
日本研究人员和公众对体外培养 14 天以上的人类胚胎文化的调查。
Stem Cell Reports. 2023 Apr 11;18(4):799-806. doi: 10.1016/j.stemcr.2023.02.005. Epub 2023 Mar 23.
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用社会理解促进体外配子发生研究。
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