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与疫苗接种覆盖率相关的 SARS-CoV-2 德尔塔变体和非德尔塔变体的病例病死率风险差异:英国的一项早期生态学研究。

Differences in the case fatality risks associated with SARS-CoV-2 Delta and non-Delta variants in relation to vaccine coverage: An early ecological study in the United Kingdom.

机构信息

JC School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong, China; CUHK Shenzhen Research Institute, Shenzhen, China.

JC School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong, China.

出版信息

Infect Genet Evol. 2022 Jan;97:105162. doi: 10.1016/j.meegid.2021.105162. Epub 2021 Nov 27.

DOI:10.1016/j.meegid.2021.105162
PMID:34843993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8626151/
Abstract

The circulation of SARS-CoV-2 Delta (i.e., B.1.617.2) variants challenges the pandemic control. Our analysis showed that in the United Kingdom (UK), the reported case fatality ratio (CFR) decreased from May to July 2021 for non-Delta variant, whereas the decreasing trends of the CFR of Delta variant appeared weak and insignificant. The association between vaccine coverage and CFR might be stratified by different circulating variants. Due to the limitation of ecological study design, the interpretation of our results should be treated with caution.

摘要

SARS-CoV-2 德尔塔(即 B.1.617.2)变体的传播对大流行的控制构成挑战。我们的分析表明,在英国(UK),2021 年 5 月至 7 月,非德尔塔变体报告的病死率(CFR)下降,而德尔塔变体 CFR 的下降趋势似乎较弱且不显著。疫苗接种覆盖率与 CFR 之间的关联可能因不同的循环变体而有所不同。由于生态研究设计的局限性,我们的研究结果的解释应谨慎对待。

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