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营养与皮肤创伤愈合。

Nutrition and cutaneous wound healing.

机构信息

Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts, USA.

Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts, USA.

出版信息

Clin Dermatol. 2022 Mar-Apr;40(2):103-113. doi: 10.1016/j.clindermatol.2021.10.002. Epub 2021 Oct 26.

Abstract

Wound healing is a complex and energy-demanding process. The relationship between nutrition and wound healing has been recognized for many centuries. Several studies have indicated that nutritional deficiencies are more prevalent among patients with chronic wounds. Malnutrition may alter the inflammatory response, collagen synthesis, and wound tensile strength, all of which are crucial for wound healing. Although the specific role of nutrition and supplementation in wound care remains uncertain, it is necessary to identify and correct nutritional imbalances to avoid any potential deterioration of the healing process. It is also important to recognize the differences in pathophysiology between acute and chronic wounds. A burn, surgical, or a traumatic wound is different from a diabetic foot ulcer, which is different from a pressure ulcer. Chronic wounds are more prevalent in the aging population, and patients often have underlying comorbidities, such as diabetes mellitus, peripheral vascular disease, connective tissue disease, or other systemic illnesses that may alter energy metabolism and contribute to impaired healing. Management approaches to acute wound care may not apply universally to chronic wounds. In this review, we discuss the available data and possible roles for nutrition in wound healing.

摘要

伤口愈合是一个复杂且耗能的过程。营养与伤口愈合之间的关系已被人们认识了数个世纪。多项研究表明,慢性伤口患者更容易出现营养缺乏。营养不良可能会改变炎症反应、胶原蛋白合成和伤口拉伸强度,这些都是伤口愈合的关键因素。尽管营养和补充剂在伤口护理中的具体作用仍不确定,但有必要识别和纠正营养失衡,以避免愈合过程的任何潜在恶化。认识到急性和慢性伤口之间的病理生理学差异也很重要。烧伤、手术或创伤性伤口与糖尿病足溃疡不同,糖尿病足溃疡又与压力性溃疡不同。慢性伤口在老年人群中更为常见,患者通常存在潜在的合并症,如糖尿病、周围血管疾病、结缔组织疾病或其他全身性疾病,这些疾病可能会改变能量代谢并导致愈合受损。急性伤口护理的管理方法可能并不适用于所有慢性伤口。在这篇综述中,我们讨论了营养在伤口愈合中的可用数据和可能作用。

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