帕金森病冻结步态患者的脑脊液生物标志物：一项探索性分析。
Cerebrospinal fluid biomarkers in Parkinson's disease with freezing of gait: an exploratory analysis.
作者信息
Hatcher-Martin J M, McKay J L, Pybus A F, Sommerfeld B, Howell J C, Goldstein F C, Wood L, Hu W T, Factor S A
机构信息
Jean & Paul Amos PD & Movement Disorders Program, Department of Neurology, Emory University, Atlanta, GA, USA.
Department of Neurology, SOC Telemed, Atlanta, GA, USA.
出版信息
NPJ Parkinsons Dis. 2021 Nov 29;7(1):105. doi: 10.1038/s41531-021-00247-x.
We explore the association between three Alzheimer's disease-related and ten inflammation-related CSF markers and freezing of gait (FOG) in patients with Parkinson's disease (PD). The study population includes PD patients with FOG (PD-FOG, N = 12), without FOG (PD-NoFOG, N = 19), and healthy controls (HC, N = 12). Age and PD duration are not significantly different between groups. After adjusting for covariates and multiple comparisons, the anti-inflammatory marker, fractalkine, is significantly decreased in the PD groups compared to HC (P = 0.002), and further decreased in PD-FOG compared to PD-NoFOG (P = 0.007). The Alzheimer's disease-related protein, Aβ42, is increased in PD-FOG compared to PD-NoFOG and HC (P = 0.001). Group differences obtained in individual biomarker analyses are confirmed with multivariate discriminant partial least squares regression (P < 0.001). High levels of Aβ42 in PD-FOG patients supports an increase over time from early to advanced state. Low levels of fractalkine might suggest anti-inflammatory effect. These findings warrant replication.
我们探讨了帕金森病（PD）患者中三种与阿尔茨海默病相关的脑脊液标志物和十种与炎症相关的脑脊液标志物与步态冻结（FOG）之间的关联。研究人群包括有步态冻结的PD患者（PD-FOG，N = 12）、无步态冻结的PD患者（PD-NoFOG，N = 19）和健康对照者（HC，N = 12）。各组之间的年龄和PD病程无显著差异。在对协变量和多重比较进行校正后，与HC相比，抗炎标志物趋化因子在PD组中显著降低（P = 0.002），与PD-NoFOG相比，在PD-FOG中进一步降低（P = 0.007）。与PD-NoFOG和HC相比，与阿尔茨海默病相关的蛋白Aβ42在PD-FOG中升高（P = 0.001）。通过多变量判别偏最小二乘回归证实了个体生物标志物分析中获得的组间差异（P < 0.001）。PD-FOG患者中高水平的Aβ42支持从早期到晚期随时间增加。趋化因子水平低可能提示抗炎作用。这些发现有待重复验证。
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