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自体骨髓源软骨细胞治疗膝关节骨关节炎患者：一项随机对照试验。

Autologous Bone Marrow-Derived Chondrocytes for Patients with Knee Osteoarthritis: A Randomized Controlled Trial.

作者信息

Sadat-Ali Mir, AlOmran Abdallah S, AlMousa Sulaiman A, AlSayed Hasan N, AlTabash Khalid W, Azam Mohammed Q, Hegazi Tarek M, Acharya Sadananda

机构信息

Department of Orthopaedic Surgery, Imam AbdulRahman Bin Faisal University, Dammam, Saudi Arabia.

King Fahd Hospital of the University, AlKhobar, Saudi Arabia.

出版信息

Adv Orthop. 2021 Nov 20;2021:2146722. doi: 10.1155/2021/2146722. eCollection 2021.

DOI:10.1155/2021/2146722
PMID:34845428
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8627347/
Abstract

RESULTS

There were a total of 60 patients who were followed up. Three patients in Group II were removed from the analysis as they underwent total knee arthroplasty (TKA). A notably significant improvement was noticed in the ABMDC group on all scores of VAS and MKSSSF with < 0.0001. The control group continued to be dissatisfied with the treatment they were taking.

CONCLUSIONS

This study reveals that a single injection of 5 million of ABMDC was efficient in reducing the symptoms, improving the functional score and betterment of QOL.

摘要

结果

共有60例患者接受随访。第二组中有3例患者因接受全膝关节置换术（TKA）而被排除在分析之外。ABMDC组在VAS和MKSSSF的所有评分上均有显著改善，P<0.0001。对照组对其正在接受的治疗仍不满意。

结论

本研究表明，单次注射500万单位的ABMDC可有效减轻症状、改善功能评分并提高生活质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ea8/8627347/839afa517e38/aorth2021-2146722.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ea8/8627347/486a1caae19f/aorth2021-2146722.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ea8/8627347/839afa517e38/aorth2021-2146722.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ea8/8627347/486a1caae19f/aorth2021-2146722.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ea8/8627347/839afa517e38/aorth2021-2146722.002.jpg

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