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肽衍生生物传感器及其在肿瘤免疫相关检测中的应用。

Peptide-Derived Biosensors and Their Applications in Tumor Immunology-Related Detection.

机构信息

Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photoelectronic/Electro-photonic Conversion Materials, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, People's Republic of China.

出版信息

Anal Chem. 2022 Jan 11;94(1):431-441. doi: 10.1021/acs.analchem.1c04461. Epub 2021 Nov 30.

Abstract

Small-molecular targeting peptides possess features of biocompatibility, affinity, and specificity, which is widely applied in molecular recognition and detection. Moreover, peptides can be developed into highly ordered supramolecular assemblies with boosting binding affinities, diverse functions, and enhanced stabilities suitable for biosensors construction. In this Review, we summarize recent progress of peptide-based biosensors for precise detection, especially on tumor-related analysis, as well as further provide a brief overview of the progress in tumor immune-related detection. Also, we are looking forward to the prospective future of peptide-based biosensors.

摘要

小分子靶向肽具有生物相容性、亲和力和特异性等特点,广泛应用于分子识别和检测。此外,肽可以被开发成具有增强的结合亲和力、多种功能和增强的稳定性的高度有序的超分子组装体,适用于生物传感器的构建。在这篇综述中,我们总结了基于肽的生物传感器在精确检测方面的最新进展,特别是在肿瘤相关分析方面,同时还简要概述了肿瘤免疫相关检测方面的进展。此外,我们对基于肽的生物传感器的未来发展前景进行了展望。

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