Mokgalaboni Kabelo, Ntamo Yonela, Ziqubu Khanyisani, Nyambuya Tawanda M, Nkambule Bongani B, Mazibuko-Mbeje Sithandiwe E, Gabuza Kwazikwakhe B, Chellan Nireshni, Tiano Luca, Dludla Phiwayinkosi V
School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.
Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa.
Food Funct. 2021 Dec 13;12(24):12235-12249. doi: 10.1039/d1fo02696h.
Oxidative stress and inflammation remain the major complications implicated in the development and progression of metabolic complications, including obesity, type 2 diabetes (T2D) and nonalcoholic fatty liver disease (NAFLD). In fact, due to their abundant antioxidant and anti-inflammatory properties, there is a general interest in understanding the therapeutic effects of some major food-derived bioactive compounds like curcumin against diverse metabolic diseases. Hence, a systematic search, through prominent online databases such as MEDLINE, Scopus, and Google Scholar was done focusing on randomized controlled trials (RCTs) reporting on the impact of curcumin supplementation in individuals with diverse metabolic complications, including obesity, T2D and NAFLD. Summarized findings suggest that curcumin supplementation can significantly reduce blood glucose and triglycerides levels, including markers of liver function like alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in patients with T2D and NAFLD. Importantly, this effect was consistent with the reduction of predominant markers of oxidative stress and inflammation, such as the levels of malonaldehyde (MDA), tumor necrosis factor-alpha (TNF-α), high sensitivity C-reactive protein (hs-CRP) and monocyte chemoattractant protein-1 (MCP-1) in these patients. Although RCTs suggest that curcumin is beneficial in ameliorating some metabolic complications, future research is still necessary to enhance its absorption and bioavailability profile, while also optimizing the most effective therapeutic doses.
氧化应激和炎症仍然是肥胖、2型糖尿病（T2D）和非酒精性脂肪性肝病（NAFLD）等代谢并发症发生和发展的主要相关并发症。事实上，由于一些主要的食物来源生物活性化合物（如姜黄素）具有丰富的抗氧化和抗炎特性，人们普遍有兴趣了解它们对各种代谢性疾病的治疗作用。因此，通过MEDLINE、Scopus和谷歌学术等著名在线数据库进行了系统检索，重点关注随机对照试验（RCT），这些试验报告了补充姜黄素对患有肥胖、T2D和NAFLD等各种代谢并发症的个体的影响。总结的研究结果表明，补充姜黄素可以显著降低T2D和NAFLD患者的血糖和甘油三酯水平，包括肝功能指标如丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）。重要的是，这种效果与氧化应激和炎症的主要标志物水平降低一致，如这些患者的丙二醛（MDA）、肿瘤坏死因子-α（TNF-α）、高敏C反应蛋白（hs-CRP）和单核细胞趋化蛋白-1（MCP-1）水平。虽然随机对照试验表明姜黄素在改善一些代谢并发症方面有益，但未来仍需要进一步研究以提高其吸收和生物利用度，同时优化最有效的治疗剂量。
