Department of Pharmaceutical Chemistry, Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, MS, India (Affiliated to the Savitribai Phule Pune University, Pune, India).
Curr Drug Discov Technol. 2022;19(3):e301121198426. doi: 10.2174/1570163819666211130141442.
Over recent years, there has been tremendous research focused on the effective utilization of natural products in wound management. Natural or herbal products contain several phytoconstituents that may act on various stages in wound healing and thereby provide a multi-targeted approach especially in the treatment of chronic wounds. Currently, attempts have been made to screen the phytoconstituents present in herbs on various targets involved in wound healing. This review includes a systematic evaluation of scientific reports by various groups of researchers on the herbals evaluated for wound management, their phytochemical profiling, pre-clinical studies, and molecular modeling studies. Various wound targets discussed include Interleukin-1, Interleukin-6, Tumor necrosis factor-α (TNF-α), Thymosin beta-4 (Tβ-4) that regulate the early inflammatory stage and the novel T cell immune response cDNA 7(TIRC7) that regulates angiogenesis. Also, neuropeptides P and Y act on the inflammatory, migratory, and proliferation phases, and growth factors like vascular endothelial growth factor family (VEGF) and placental growth factor family (PGF) are involved in angiogenesis, while the role of Fibroblast growth factor in tissue remodeling is discussed. As many of the natural products include polyherbal systems, this approach can help in the judicious selection of a combination of herbs that will act on multiple targets in the wound healing process and provide a multi-factorial approach in wound management.
近年来，人们对天然产物在伤口管理中的有效利用进行了大量研究。天然或草药产品含有多种植物成分，这些成分可能作用于伤口愈合的各个阶段，从而提供一种多靶点的方法，特别是在治疗慢性伤口方面。目前，已经尝试筛选草药中针对各种与伤口愈合相关靶点的植物成分。本综述包括对不同研究小组评估草药用于伤口管理的研究报告进行系统评价，包括其植物化学成分分析、临床前研究和分子建模研究。讨论的各种伤口靶点包括白细胞介素-1、白细胞介素-6、肿瘤坏死因子-α（TNF-α）、胸腺素β-4（Tβ-4），它们调节早期炎症阶段和新的 T 细胞免疫反应 cDNA7（TIRC7），调节血管生成。此外，神经肽 P 和 Y 作用于炎症、迁移和增殖阶段，血管内皮生长因子家族（VEGF）和胎盘生长因子家族（PGF）等生长因子参与血管生成，而纤维母细胞生长因子在组织重塑中的作用也有所讨论。由于许多天然产物包括多种草药系统，这种方法有助于明智地选择多种草药的组合，这些草药将作用于伤口愈合过程中的多个靶点，并提供一种多因素的伤口管理方法。
