Bisetegn Habtye, Eshetu Tegegne, Erkihun Yonas
College of Medicine and Health Sciences, Department of Medical Laboratory Sciences, Wollo University, Dessie, Ethiopia.
College of Medicine and Health Sciences, School of Biomedical and Laboratory Sciences, Department of Medical Parasitology, University of Gondar, Gondar, Ethiopia.
Trop Dis Travel Med Vaccines. 2021 Dec 1;7(1):30. doi: 10.1186/s40794-021-00156-0.
Schistosomiasis is a neglected tropical disease caused by mainly Schistosoma mansoni and Schistosoma hematobium. The disease is very common in Africa including Ethiopia. Schistosoma mansoni is a major public health problem in Ethiopia especially among children. This review is aimed to indicate the prevalence of Schistosoma mansoni among children at the national and regional levels.
The PRISMA guidelines were followed. An electronic search of PubMed, Google Scholar, Web of Science, Scopus, MEDLINE, and Google search were carried out using key terms. Articles published from the proceeding of professional associations such as the Ethiopian medical laboratory association, the Ethiopian public health association, and annual national research conferences were also searched to find additional eligible studies. Data were extracted independently by two investigators, and cross-checked by a third reviewer. The quality of included studies was assessed using JBI quality assessment criteria. Data were extracted using Microsoft excel and finally analyzed using STATA version 12. The pooled prevalence was done using a random-effects model.
Overall 49 studies involving 20,493 children (10,572 male and 9, 921 females) were included in this meta-analysis. The pooled prevalence of Schistosoma mansoni infection was 37.13% (95%CI:30.02-44.24). High heterogeneity was observed with I of 99.4%, P < 0.000. According to subgroup analysis, the pooled prevalence was high in the SNNPR (41.49%: 95%CI: 19.52-63.46) followed by the Amhara region (41.11%: 95%CI: 30.41-51.8), the Tigray region (31.40%: 95%CI:11.72-51.09), and the Oromia region (28.98%: 95%CI: 18.85-39.1). Year from 2011 to 2015 contributed to the highest prevalence of Schistosoma mansoni infection among children (46.31%: 95%:34.21-59.05).
This study revealed a 37.13% prevalence of Schistosoma mansoni infection among children. This is an alert to improve and implement appropriate control strategies such as mass drug administration in Ethiopia.
血吸虫病是一种被忽视的热带疾病，主要由曼氏血吸虫和埃及血吸虫引起。该疾病在包括埃塞俄比亚在内的非洲非常常见。曼氏血吸虫是埃塞俄比亚的一个主要公共卫生问题，尤其是在儿童中。本综述旨在表明曼氏血吸虫在国家和地区层面儿童中的流行情况。
遵循PRISMA指南。使用关键词对PubMed、谷歌学术、科学网、Scopus、MEDLINE和谷歌搜索进行电子检索。还检索了埃塞俄比亚医学实验室协会、埃塞俄比亚公共卫生协会等专业协会会议记录以及年度国家研究会议上发表的文章，以寻找其他符合条件的研究。由两名研究人员独立提取数据，并由第三名审阅者进行交叉核对。使用JBI质量评估标准评估纳入研究的质量。使用Microsoft excel提取数据，最后使用STATA 12版本进行分析。采用随机效应模型计算合并患病率。
本荟萃分析共纳入49项研究，涉及20493名儿童（10572名男性和9921名女性）。曼氏血吸虫感染的合并患病率为37.13%（95%CI：30.02 - 44.24）。观察到高度异质性，I为99.4%，P < 0.000。根据亚组分析，合并患病率在南方各族州最高（41.49%：95%CI：19.52 - 测63.46），其次是阿姆哈拉地区（41.11%：95%CI：30.41 - 51.8）、提格雷地区（31.40%：95%CI：11.72 - 51.09）和奥罗米亚地区（28.98%：95%CI：18.85 - 39.1）。2011年至2015年期间儿童曼氏血吸虫感染患病率最高（46.31%：95%：34.21 - 59.05）。
本研究显示儿童曼氏血吸虫感染患病率为37.13%。这警示埃塞俄比亚要改进并实施适当的控制策略，如大规模药物治疗。
