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使用基于石墨烯的材料作为生物活性剂的载体。

Use of graphene-based materials as carriers of bioactive agents.

作者信息

Lai Wing-Fu, Wong Wing-Tak

机构信息

Ciechanover Institute of Precision and Regenerative Medicine, School of Life and Health Sciences, The Chinese University of Hong Kong (Shenzhen), Shenzhen 518172, China.

Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hong Kong, Special Administrative Region, China.

出版信息

Asian J Pharm Sci. 2021 Sep;16(5):577-588. doi: 10.1016/j.ajps.2020.11.004. Epub 2020 Dec 7.

Abstract

Graphene possesses a large specific surface area, a high Young's modulus, high fracture strength, high electrical conductivity, and excellent optical performance. It has been widely studied for biomedical use since its first appearance in the literature. This article offers an overview of the latest advances in the design of graphene-based materials for delivery of bioactive agents. To enhance the translation of these carriers into practical use, the toxicity involved is needed to be examined in future research in more detail. In addition, guidelines for standardizing experimental conditions during the evaluation of the performance of graphene-based materials are required to be established so that candidates showing higher practical potential can be more effectively identified for further development. This can streamline the optimization and use of graphene-based materials in delivery applications.

摘要

石墨烯具有大的比表面积、高杨氏模量、高断裂强度、高电导率和优异的光学性能。自其首次出现在文献中以来,就已被广泛研究用于生物医学领域。本文概述了用于生物活性剂递送的石墨烯基材料设计的最新进展。为了促进这些载体在实际应用中的转化,未来的研究需要更详细地研究其涉及的毒性。此外,需要建立在评估石墨烯基材料性能时标准化实验条件的指导方针,以便更有效地识别具有更高实际潜力的候选材料以进行进一步开发。这可以简化石墨烯基材料在递送应用中的优化和使用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f738/8609387/d109ec26c1c2/fx1.jpg

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