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Mesalamine Reduces Intestinal ACE2 Expression Without Modifying SARS-CoV-2 Infection or Disease Severity in Mice.

作者信息

Alvarado David M, Son Juhee, Thackray Larissa B, Gomez Castro Maria Florencia, Prasad Sarada, Cui Xueyang, Sonnek Naomi M, Diamond Michael S, Ding Siyuan, Ciorba Matthew A

机构信息

From the ∗Inflammatory Bowel Diseases Center, Division of Gastroenterology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.

Department of Molecular Microbiology, Washington University in St. Louis, St. Louis, MO, USA.

出版信息

Inflamm Bowel Dis. 2022 Feb 1;28(2):318-321. doi: 10.1093/ibd/izab274.

Abstract
摘要

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本文引用的文献

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Impact of Medications on COVID-19 Outcomes in Inflammatory Bowel Disease: Analysis of More Than 6000 Patients From an International Registry.
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Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell.
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Intestinal Host Response to SARS-CoV-2 Infection and COVID-19 Outcomes in Patients With Gastrointestinal Symptoms.
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SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function.
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TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes.
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