Department of Pathology & Toxicology, Shenzhen Prevention and Treatment Center for Occupational Diseases, Shenzhen, China.
National Key Clinical Specialty of Occupational Diseases, Shenzhen Prevention and Treatment Center for Occupational Diseases, Shenzhen, China.
World J Microbiol Biotechnol. 2021 Dec 1;38(1):9. doi: 10.1007/s11274-021-03198-w.
Cadmium (Cd) pollution has become a global environmental issue because Cd gets easily accumulated and translocated in the food chain, threatening human health. Considering the detrimental effects and non-biodegradability of environmental Cd, this is an urgent issue that needs to be addressed through the development of robust, cost-effective, and eco-friendly green routes for monitoring and remediating toxic levels of Cd. This article attempts to review various bacterial approaches toward biosensing and bioremediation of Cd in the environment. This review focuses on the recent development of bacterial cell-based biosensors for the detection of bioavailable Cd and the bioremediation of toxic Cd by natural or genetically-engineered bacteria. The present limitations and future perspectives of these available bacterial approaches are outlined. New trends for integrating synthetic biology and metabolic engineering into the design of bacterial biosensors and bioadsorbers are additionally highlighted.
镉(Cd)污染已成为全球性的环境问题,因为 Cd 很容易在食物链中积累和转移,威胁人类健康。考虑到环境 Cd 的有害影响和不可生物降解性,这是一个亟待解决的问题,需要通过开发强大、经济高效和环保的绿色途径来监测和修复有毒水平的 Cd。本文试图综述各种细菌方法在环境中 Cd 的生物传感和生物修复方面的应用。本综述重点介绍了基于细菌细胞的生物传感器在检测生物可利用 Cd 以及利用天然或基因工程细菌进行有毒 Cd 生物修复方面的最新进展。概述了这些现有细菌方法的当前局限性和未来展望。此外,还强调了将合成生物学和代谢工程整合到细菌生物传感器和生物吸附剂的设计中的新趋势。