Andersch B, Forssman L, Lincoln K, Torstensson P
Gynecol Obstet Invest. 1986;21(1):19-25. doi: 10.1159/000298923.
Bacteriological isolation of anaerobes, Gardnerella and lactobacilli was carried out in a group of 62 women with the diagnosis bacterial vaginosis and 42 control women. Lactobacilli were the predominant organisms in the control group whereas anaerobes dominated the flora in bacterial vaginosis patients. Lactate-gel (pH 3.5, 5 ml) inserted into the vagina daily for 7 days is as effective as oral metronidazole, 500 mg twice daily for 7 days. The women in both groups became symptom-free and objectively improved. Anaerobes were significantly reduced (p less than 0.0001) in both groups after 1-week treatment but Gardnerella was not significantly reduced. As bacterial vaginosis is generally looked upon as a mild noninflammatory condition lactate-gel seems to be an ideal treatment for this disease.
对62名诊断为细菌性阴道病的女性和42名对照女性进行了厌氧菌、加德纳菌和乳酸杆菌的细菌学分离。乳酸杆菌是对照组中的主要微生物，而厌氧菌在细菌性阴道病患者的菌群中占主导地位。每天向阴道内插入乳酸凝胶（pH 3.5，5毫升），持续7天，其效果与口服甲硝唑（500毫克，每日两次，共7天）相同。两组女性均症状消失且客观上有所改善。治疗1周后，两组中的厌氧菌均显著减少（p<0.0001），但加德纳菌未显著减少。由于细菌性阴道病通常被视为一种轻度非炎症性疾病，乳酸凝胶似乎是治疗该病的理想方法。
