埃塞俄比亚西北部的血液系统恶性肿瘤。

Hematological malignancies in the Northwest Ethiopia.

机构信息

University of Gondar, College of Medicine and Health Science, School of Biomedical and Laboratory Sciences, Department of Hematology and Immunohematology, Gondar, Ethiopia.

University of Gondar, College of Medicine and Health Science, School of Medicine, Department of Pathology, Gondar, Ethiopia.

出版信息

PLoS One. 2021 Dec 1;16(12):e0260639. doi: 10.1371/journal.pone.0260639. eCollection 2021.

DOI:10.1371/journal.pone.0260639

PMID:34852010

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8635328/

Abstract

BACKGROUND

The effect of malignant diseases is increasing globally, particularly in developing countries as shown by recent cancer statistics from the world health organization reports. It is anticipated that with an increase in life expectancy consequent upon the improved standard of living and increasing urbanization, the burden of hematological malignancies in sub-Saharan Africa particularly in Ethiopia is likely to increase recently. Therefore, this study was aimed to determine the incidence and trend of hematological malignancy in Northwest Ethiopia.

METHODS

A facility-based retrospective study was conducted from 2015 to 2019 at the University of Gondar and Bahir-Dar Felegehiwot comprehensive specialized hospitals. Hematological malignancy data were collected by using a data collection sheet that was consisted of patients' socio-demography, clinical, and laboratory data. Then, data were entered into Epi-info 3.5.1 and exported to SPSS version 20 for analysis. Skewness and kurtosis were used to check data distribution. Descriptive statistics were summarized as percentages, means, and standard deviations of background variables, and the trend were analyzed.

RESULTS

In this study, a total of 1,342 study participants were included. The mean age of study participants was 41.49 ± 16.3 years with a range of 1 to 92 years. About 58.3%, 52.2%, and 80% of the cases were observed among males, 18-45 age group, and urban residences, respectively. Of the total cases, 92.9% and 7.1% were lymphoma and leukemia, respectively. On the other hand, from lymphoma cases, 72.3% and 27.7% were HL and NHL, respectively while from leukemic cases, 61.1%, 23.2, 6.3%, 4.2%, and 5.3% were CLL, ALL, CML, AML, and other HM types, respectively. In this study, there was no trend.

CONCLUSION

We concluded that lymphoma was the dominant type of hematological malignancy observed in northwest Ethiopia. The study indicated that the majority of cases were observed among male, urban residents, and adult populations aged 18-45 years. Therefore, special focus should be given to the highly affected population. Further, a prospective cohort study should be conducted for a better understanding of the prevalence and associated factors to it.

摘要

背景

恶性疾病的影响在全球范围内不断增加，特别是在发展中国家，世界卫生组织最近的癌症统计数据显示了这一点。预计随着生活水平的提高和城市化进程的加快，预期寿命的延长，撒哈拉以南非洲，特别是埃塞俄比亚的血液系统恶性肿瘤负担将最近增加。因此，本研究旨在确定西北埃塞俄比亚血液系统恶性肿瘤的发病率和趋势。

方法

这是一项在 2015 年至 2019 年期间在贡德尔大学和巴赫达尔费莱吉沃特综合专科医院进行的基于机构的回顾性研究。使用包含患者社会人口统计学、临床和实验室数据的数据收集表收集血液系统恶性肿瘤数据。然后，将数据输入 Epi-info 3.5.1 并导出到 SPSS 版本 20 进行分析。偏度和峰度用于检查数据分布。描述性统计数据以背景变量的百分比、平均值和标准差进行总结，并分析趋势。

结果

在这项研究中，共有 1342 名研究参与者被纳入。研究参与者的平均年龄为 41.49 ± 16.3 岁，范围为 1 至 92 岁。男性、18-45 岁年龄组和城市居民分别占病例的 58.3%、52.2%和 80%。在所有病例中，淋巴瘤和白血病分别占 92.9%和 7.1%。另一方面，淋巴瘤病例中，霍奇金淋巴瘤和非霍奇金淋巴瘤分别占 72.3%和 27.7%，而白血病病例中，慢性淋巴细胞白血病、急性淋巴细胞白血病、慢性髓性白血病、急性髓性白血病和其他血液系统恶性肿瘤类型分别占 61.1%、23.2%、6.3%、4.2%和 5.3%。在这项研究中，没有趋势。