SARS-CoV-2 实验室检测方法和技术应用的进展。
Advances in laboratory detection methods and technology application of SARS-CoV-2.
机构信息
The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, China.
出版信息
J Med Virol. 2022 Apr;94(4):1357-1365. doi: 10.1002/jmv.27494. Epub 2021 Dec 10.
Abstract
At present, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is raging worldwide, and the coronavirus disease 2019 outbreak caused by SARS-CoV-2 seriously threatens the life and health of all humankind. There is no specific medicine for novel coronavirus yet. So, laboratory diagnoses of novel coronavirus as soon as possible and isolation of the source of infection play a vital role in preventing and controlling the epidemic. Therefore, selecting appropriate detection techniques and methods is particularly important to improve the efficiency of disease diagnosis and treatment and to curb the outbreak of infectious diseases. In this paper, virus nucleic acid, protein, and serum immunology were reviewed to provide a reference for further developing virus detection technology to provide better prevention and treatment strategies and research ideas for clinicians and researchers.
摘要
目前，严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）正在全球肆虐，由 SARS-CoV-2 引起的 2019 年冠状病毒病严重威胁着全人类的生命和健康。目前还没有针对新型冠状病毒的特效药。因此，尽快对新型冠状病毒进行实验室诊断，并对感染源进行隔离，对于防控疫情至关重要。因此，选择合适的检测技术和方法对于提高疾病诊断和治疗的效率，遏制传染病的爆发尤为重要。本文综述了病毒核酸、蛋白质和血清免疫学，以期为进一步开发病毒检测技术提供参考，为临床医生和研究人员提供更好的防治策略和研究思路。
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