Cardiovascular Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
J Int Med Res. 2021 Dec;49(12):3000605211059893. doi: 10.1177/03000605211059893.
Smoking is a risk factor for coronary artery disease (CAD) and a known factor influencing the severity and pattern of CAD. We summarized evidence regarding the effect of smoking on the number of occluded coronary arteries and the severity and pattern of CAD.
We extracted data from observational studies reporting the pattern and severity of CAD in smokers. The quality of studies was assessed using the Strengthening the Reporting of Observational Studies in Epidemiology checklist, and results are reported in the Garrard table. The review process followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement.
We screened 11 studies including 6037 samples. Six studies reported no relationship between smoking and the number of damaged arteries. One study reported that smoking was related to occlusion in the left anterior descending artery, but there was no relationship between smoking and the location of occlusion in the arteries. Smoking was related to CAD severity in five studies.
Smoking was found to be related to CAD severity and location of the damaged artery in the heart. However, there was no significant association of smoking with the number of damaged arteries and location of arterial occlusion.
吸烟是冠心病（CAD）的一个风险因素，也是影响 CAD 严重程度和模式的已知因素。我们总结了关于吸烟对闭塞冠状动脉数量以及 CAD 的严重程度和模式的影响的证据。
我们从报告吸烟者 CAD 模式和严重程度的观察性研究中提取数据。使用流行病学观察研究强化报告清单评估研究质量，并在 Garrard 表中报告结果。审查过程遵循系统评价和荟萃分析的首选报告项目声明。
我们筛选了 11 项研究，包括 6037 个样本。六项研究报告称吸烟与受损动脉数量之间没有关系。一项研究报告称，吸烟与左前降支的闭塞有关，但吸烟与动脉闭塞的位置之间没有关系。五项研究表明吸烟与 CAD 严重程度有关。
吸烟与 CAD 严重程度和心脏受损动脉的位置有关。然而，吸烟与受损动脉的数量和动脉闭塞的位置没有显著关联。
