Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
PLoS One. 2021 Dec 2;16(12):e0259447. doi: 10.1371/journal.pone.0259447. eCollection 2021.
Lung cancer is characterized by high morbidity and mortality rates, and it has become an important public health issue worldwide. The occurrence and development of tumors is a multi-gene and multi-stage complex process. As an oncogene, ribosomal oxygenase 2 (RIOX2) has been associated with a variety of cancers. In this article, we analyzed the correlation between RIOX2 expression and methylation in lung cancer based on the databases including the cancer genome atlas (TCGA) (https://portal.gdc.cancer.gov/) and the gene expression omnibus (GEO) (https://www.ncbi.nlm.nih.gov/geo/). It was found that RIOX2 is highly expressed in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) tissues, whose expression is negatively correlated with its methylation level. In this regard, methylation at cg09716038, cg14773523, cg14941179, and cg22299097 had a significant negative correlation with RIOX2 expression in LUAD, whereas in LUSC, methylation at cg09716038, cg14773523, cg14941179, cg22299097, cg05451573, cg10779801, and cg23629183 is negatively correlated with RIOX2 expression. According to the analysis based on the databases, RIOX2 gene could not be considered as the independent prognostic biomarker in lung adenocarcinoma or squamous cell lung cancer. However, the molecular mechanism of RIOX2 gene in the development of lung cancer may be helpful in improving lung cancer therapy.
肺癌的发病率和死亡率都很高，已成为全球重要的公共卫生问题。肿瘤的发生和发展是一个多基因、多阶段的复杂过程。核糖体氧化酶 2（RIOX2）作为一种癌基因，与多种癌症有关。本文基于癌症基因组图谱（TCGA）（https://portal.gdc.cancer.gov/）和基因表达综合数据库（GEO）（https://www.ncbi.nlm.nih.gov/geo/）等数据库，分析了 RIOX2 表达与肺癌甲基化的相关性。结果发现，RIOX2 在肺腺癌（LUAD）和肺鳞癌（LUSC）组织中高表达，其表达与甲基化水平呈负相关。在 LUAD 中，cg09716038、cg14773523、cg14941179 和 cg22299097 位点的甲基化与 RIOX2 表达呈显著负相关，而在 LUSC 中，cg09716038、cg14773523、cg14941179、cg22299097、cg05451573、cg10779801 和 cg23629183 位点的甲基化与 RIOX2 表达呈负相关。基于数据库的分析结果显示，RIOX2 基因不能作为肺腺癌或肺鳞癌的独立预后生物标志物。然而，RIOX2 基因在肺癌发生发展中的分子机制可能有助于改善肺癌的治疗。
