Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China.
Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China.
Mater Sci Eng C Mater Biol Appl. 2021 Dec;131:112504. doi: 10.1016/j.msec.2021.112504. Epub 2021 Oct 24.
MnO owns distinct redox, imaging, and degradable properties corresponding to the tumor microenvironment. However, the onefold structure and non-modifiable property cause many obstacles to anticancer applications. In this report, we first prepared a typical core-shell gold nanorod (GNR)/manganese dioxide (MnO) nanoparticles (GNR/MnO NPs). Interestingly, the MnO had a mesoporous channel and modifiable hydroxyl group (OH). Here, the unique 'OH' groups were modified and further grafted with poly(N-isopropylacrylamide-co-acrylic acid) (PNA). As a dual-sensitive hydrogel, it was selected as the thermal/pH-sensitive component in the hybrid nanoparticles (GNR/MnO/PNA NPs). The anticancer drug doxorubicin hydrochloride (DOX) was selected and loaded into the hybrid nanoparticles (GNR/MnO/PNA-DOX NPs). The GNR/MnO/PNA NPs achieved satisfying drug-loading efficiency and glutathione (GSH)/pH/thermal-responsive drug-controlled release. As a side benefit, the GNR/MnO/PNA NPs showed potential as excellent near-infrared (NIR)-excited nanoplatforms for photothermal therapy (PTT). Delightedly, the studies demonstrated that the GNR/MnO/PNA-DOX NPs showed a noticeable killing effect on tumor cells, whether it is tumor cell-triggered drug release or photothermal effect. Besides, it not only could enhance mitochondrial damage but also could inhibit the migration and invasion of tumor cells. Quite the reverse, it had little negative impact on normal cells. The feature can prevent anticancer drugs and nanoparticles from killing normal cells. Consequently, GNR/MnO/PNA NPs have potential applications in drug delivery and synergistic therapy due to these advantageous features.
MnO 具有独特的氧化还原、成像和可降解特性，对应于肿瘤微环境。然而，单一的结构和不可修改的性质给抗癌应用带来了许多障碍。在本报告中，我们首先制备了典型的核壳金纳米棒（GNR）/二氧化锰（MnO）纳米颗粒（GNR/MnO NPs）。有趣的是，MnO 具有介孔通道和可修改的羟基（OH）。在这里，独特的“OH”基团被修饰并进一步接枝上聚（N-异丙基丙烯酰胺-co-丙烯酸）（PNA）。作为一种双重敏感水凝胶，它被选择作为杂交纳米颗粒（GNR/MnO/PNA NPs）中的热/pH 敏感成分。选择抗癌药物盐酸阿霉素（DOX）并将其载入杂交纳米颗粒（GNR/MnO/PNA-DOX NPs）中。GNR/MnO/PNA NPs 实现了令人满意的载药效率和谷胱甘肽（GSH）/pH/热响应药物控制释放。作为一个附带的好处，GNR/MnO/PNA NPs 显示出作为近红外（NIR）激发的光热治疗（PTT）纳米平台的潜力。令人高兴的是，研究表明，GNR/MnO/PNA-DOX NPs 对肿瘤细胞表现出显著的杀伤作用，无论是肿瘤细胞触发的药物释放还是光热效应。此外，它不仅可以增强线粒体损伤，还可以抑制肿瘤细胞的迁移和侵袭。相反，它对正常细胞几乎没有负面影响。这种特性可以防止抗癌药物和纳米颗粒杀死正常细胞。因此，由于这些有利的特性，GNR/MnO/PNA NPs 具有在药物传递和协同治疗中的潜在应用。
