Seong Jeong Min, Park Chang Eun, Gi Mi Young, Cha Ju Ae, Moon Ae Eun, Lee Jun Ho, Sung Hyun Ho, Lim Jae Heon, Oh Suk Hee, Chung Chong Hee, Seo Eun Kyung, Yoon Hyun
Department of Dental Hygiene, College of Health Science, Kangwon National University, Samcheok-si, Gangwon-do, 25949, South Korea.
Department of Biomedical Laboratory Science, Namseoul University, Cheonan-si, Chungcheongnam-do, 31020, South Korea.
J Clin Biochem Nutr. 2021 Nov;69(3):299-304. doi: 10.3164/jcbn.21-26. Epub 2021 May 28.
This study was conducted to assess the relationship between vitamin D deficiency and anemia, by gender, in Korean adults. The data of 16,060 adults were analyzed (men, 6,840; premenopausal women, 4,916; postmenopausal women, 4,340) from the fifth Korean National Health and Nutrition Examination Survey (KNHANES V) (2010-2012). There were several key findings. First, after adjusting for related variables, the odds ratio (OR) of anemia [hemoglobin (Hb) <13 g/dl in men or Hb <12 g/dl in women] using the vitamin D normal group {25-hydroxyvitamin [25(OH)D] ≥15.0 ng/ml} as reference, was significant for the vitamin D deficient group [25(OH)D <15.0 ng/ml] in the overall population [OR, 1.310; 95% confidence interval (CI), 1.168-1.470]. Second, the OR of anemia, using the vitamin D normal group as reference, was significant for the vitamin D deficient group in premenopausal women (OR, 1.293; 95% CI, 1.105-1.513). However, vitamin D deficiency in the vitamin D normal group in men (OR, 1.093; 95% CI, 0.806-1.484) and postmenopausal women (OR, 1.130; 95% CI, 0.906-1.409) was not significant. In conclusion, Vitamin D deficiency is positively associated with anemia in premenopausal women, but not in men and postmenopausal women.
本研究旨在评估韩国成年人中维生素D缺乏与贫血之间按性别划分的关系。分析了来自韩国第五次全国健康与营养检查调查（KNHANES V）（2010 - 2012年）的16,060名成年人的数据（男性6,840名；绝经前女性4,916名；绝经后女性4,340名）。有几个关键发现。首先，在对相关变量进行调整后，以维生素D正常组{25 - 羟基维生素[25(OH)D]≥15.0 ng/ml}为参照，维生素D缺乏组[25(OH)D < 15.0 ng/ml]的贫血（男性血红蛋白（Hb）< 13 g/dl或女性Hb < 12 g/dl）优势比（OR）在总体人群中具有统计学意义[OR，1.310；95%置信区间（CI），1.168 - 1.470]。其次，以维生素D正常组为参照，绝经前女性中维生素D缺乏组的贫血OR具有统计学意义（OR，1.293；95% CI，1.105 - 1.513）。然而，男性（OR，1.093；95% CI，0.806 - 1.484）和绝经后女性（OR，1.130；95% CI，0.906 - 1.409）中维生素D正常组的维生素D缺乏情况无统计学意义。总之，维生素D缺乏与绝经前女性的贫血呈正相关，但与男性和绝经后女性无关。
