Department of Laboratory Medicine, Green Cross Laboratories, Yongin 16924, Korea.
Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
Nutrients. 2022 May 9;14(9):1978. doi: 10.3390/nu14091978.
We retrospectively reviewed serum 25-hydroxy vitamin D (25(OH)D) test results from an adult Korean population visiting local clinics and hospitals between July 2017 and December 2021 to gather recent information on the prevalence of vitamin D deficiency. The prevalence of vitamin D deficiency status was investigated according to criteria offered by various clinical guidelines. During the study period, 180,289 subjects (29,658 men and 150,631 women) were tested for 25(OH)D. The overall prevalence rates of vitamin D deficiency status based on 25(OH)D level were as follows: 0.4% for <5 ng/mL, 12.5% for <10 ng/mL, 20.6% for <12 ng/mL, 49.4% for <20 ng/mL, and <75.3% for <30 ng/mL. Women tested their 25(OH)D level more frequently than men, and the overall prevalence of 25(OH)D < 10 ng/mL was higher among women than men, while that of 25(OH)D <30 ng/mL was lower among women than men. Among age groups, the prevalence of 25(OH)D <30 ng/mL was higher in younger patients (20s−40s, 79.6−85.5%) than older ones (≥50 years, 62.6−69.2%). The overall prevalence of vitamin D deficiency decreased over time from 2018 to 2021. Future studies are needed to clarify the clinical impact of this change.
我们回顾性分析了 2017 年 7 月至 2021 年 12 月期间在当地诊所和医院就诊的成年韩国人群的血清 25-羟维生素 D（25（OH）D）检测结果，以获取维生素 D 缺乏症的最新患病率信息。根据各种临床指南提供的标准，我们调查了维生素 D 缺乏状态的患病率。在研究期间，对 180289 名受试者（29658 名男性和 150631 名女性）进行了 25（OH）D 检测。根据 25（OH）D 水平，维生素 D 缺乏状态的总体患病率如下：<5ng/ml 为 0.4%，<10ng/ml 为 12.5%，<12ng/ml 为 20.6%，<20ng/ml 为 49.4%，<30ng/ml 为 75.3%。女性检测 25（OH）D 的频率高于男性，女性总体 25（OH）D <10ng/ml 的患病率高于男性，而女性 25（OH）D <30ng/ml 的患病率低于男性。在年龄组中，25（OH）D <30ng/ml 的患病率在年轻患者（20 多岁至 40 多岁，79.6%-85.5%）中高于老年患者（≥50 岁，62.6%-69.2%）。总体而言，2018 年至 2021 年期间，维生素 D 缺乏的总体患病率呈下降趋势。需要进一步研究阐明这种变化的临床影响。
