Jamal Wafaa, Khodakhast Fatema Bibi, Albert Manuel John, Rotimi Vincent
Department of Microbiology, Faculty of Medicine, Kuwait University, Jabriya, Kuwait.
Department of Medical Microbiology and Parasitology, College of Medicine, Lagos State University, Ikeja, Nigeria.
Infect Drug Resist. 2021 Nov 25;14:4957-4966. doi: 10.2147/IDR.S340116. eCollection 2021.
The aim of the study was to investigate the changing pattern in serogroup distribution and antimicrobial resistance of all spp. isolated from patients attending the Mubarak Al Kabeer Hospital (MAK), Kuwait from 2006 to 2020.
A retrospective study of all enrolled patients attending the MAK with culture-positive spp. was undertaken. Data on age, gender, culture sample and serogroup were obtained from the laboratory information system. A prospective antimicrobial susceptibility of all stock isolates was carried out using E test. The trend rates of serogroups and antimicrobial resistance were compared among 5 periods: 2006-2008, 2009-2011, 2012-2014, 2015-2017, and 2018-2020.
A total of 700 isolates were identified. The majority of the isolates were from the stool (77.6%), followed by the blood (16.4%). The most common serogroups were serogroup D (37.6%) and B (23.4%). There was a significant rise in ciprofloxacin resistance from 32.2% during 2006-2008 to 54.3% during 2018-2020 and from 32.5% during 2009-2011 to 54.3% during 2018-2020 (=0.0001, respectively). The resistance trend to cefotaxime was at relatively low levels ranging from 0% to 3.4% through 2006-2008 to 2018-2020. There was a significant drop of the resistance to ampicillin from 23.6% in 2015-2017 to 12.3% in 2006-2008 to 2018-2020 (=0.03). Trimethoprim/sulfamethoxazole resistance dropped significantly from 14.5 to 3.6% (=0.002) during 2006-2008 to 2018-2020 and then from 13.5 to 3.6% (=0.02) during 2015-2017 to 2018-2020. One hundred and seventeen (16.7%) isolates were multidrug-resistant.
Continuous surveillance of and its antimicrobial resistance is important for antibiotic policy formulation for invasive infections.
本研究旨在调查2006年至2020年期间从科威特穆巴拉克·卡比尔医院（MAK）就诊患者中分离出的所有[具体菌种]的血清群分布变化模式和抗菌药物耐药性。
对所有在MAK就诊且培养结果为[具体菌种]阳性的登记患者进行回顾性研究。从实验室信息系统获取年龄、性别、培养样本和血清群的数据。使用E试验对所有库存分离株进行前瞻性抗菌药物敏感性检测。比较了五个时间段（2006 - 2008年、2009 - 2011年、2012 - 2014年、2015 - 2017年和2018 - 2020年）的[具体菌种]血清群和抗菌药物耐药性的趋势率。
共鉴定出700株分离株。大多数分离株来自粪便（77.6%），其次是血液（16.4%）。最常见的血清群是D群（37.6%）和B群（23.4%）。环丙沙星耐药率从2006 - 2008年的32.2%显著上升至2018 - 2020年的54.3%，从2009 - 2011年的32.5%上升至2018 - 2020年的54.3%（分别为P = 0.0001）。头孢噻肟的耐药趋势处于相对较低水平，在2006 - 2008年至2018 - 2020年期间为0%至3.4%。氨苄西林耐药率从2015 - 2017年的23.6%显著下降至2006 - 2008年至2018 - 2020年的12.3%（P = 0.03）。甲氧苄啶/磺胺甲恶唑耐药率在2006 - 2008年至2018 - 2020年期间从14.5%显著下降至3.6%（P = 0.002），然后在2015 - 2017年至2018 - 2020年期间从13.5%下降至3.6%（P = 0.02）。117株（16.7%）分离株为多重耐药。
持续监测[具体菌种]及其抗菌药物耐药性对于制定侵袭性[具体菌种]感染的抗生素政策很重要。
