Academy of Medical Sciences, Malawi University of Science and Technology (MUST), Thyolo, Malawi.
Centre for Immunology and Vaccinology, Department of Infectious Disease, Imperial College London, London, United Kingdom.
Front Immunol. 2021 Nov 8;12:797117. doi: 10.3389/fimmu.2021.797117. eCollection 2021.
Since its emergence in 2019 SARS-CoV-2 has proven to have a higher level of morbidity and mortality compared to the other prevailing coronaviruses. Although initially most African countries were spared from the devastating effect of SARS-CoV-2, at present almost every country has been affected. Although no association has been established between being HIV-1-infected and being more vulnerable to contracting COVID-19, HIV-1-infected individuals have a greater risk of developing severe COVID-19 and of COVID-19 related mortality. The rapid development of the various types of COVID-19 vaccines has gone a long way in mitigating the devastating effects of the virus and has controlled its spread. However, global vaccine deployment has been uneven particularly in Africa. The emergence of SARS-CoV-2 variants, such as Beta and Delta, which seem to show some subtle resistance to the existing vaccines, suggests COVID-19 will still be a high-risk infection for years. In this review we report on the current impact of COVID-19 on HIV-1-infected individuals from an immunological perspective and attempt to make a case for prioritising COVID-19 vaccination for those living with HIV-1 in Sub-Saharan Africa (SSA) countries like Malawi as one way of minimising the impact of COVID-19 in these countries.
自 2019 年出现以来，SARS-CoV-2 的发病率和死亡率都明显高于其他流行的冠状病毒。尽管最初大多数非洲国家免受 SARS-CoV-2 的毁灭性影响，但目前几乎每个国家都受到了影响。虽然尚未确定 HIV-1 感染与更容易感染 COVID-19 之间存在关联，但 HIV-1 感染者患严重 COVID-19 和与 COVID-19 相关的死亡率的风险更高。各种类型的 COVID-19 疫苗的快速开发在减轻该病毒的破坏性影响方面发挥了重要作用，并控制了其传播。然而，全球疫苗的部署并不均衡，特别是在非洲。SARS-CoV-2 变体（如 Beta 和 Delta）的出现似乎显示出对现有疫苗的一些细微抗性，这表明 COVID-19 在未来几年仍将是一种高风险感染。在这篇综述中，我们从免疫学角度报告了 COVID-19 对 HIV-1 感染者的当前影响，并试图为撒哈拉以南非洲（SSA）等国家（如马拉维）的 HIV-1 感染者优先接种 COVID-19 疫苗提出建议，作为减轻这些国家 COVID-19 影响的一种方式。
