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一名既往健康的青少年在使用碘化造影剂后可能发生碘诱导的甲状腺毒症。

Possible Iodine-Induced Thyrotoxicosis in a Previously Healthy Adolescent following Administration of Iodinated Contrast Media.

作者信息

Apsan Jennifer, Antal Zoltan

机构信息

Department of Pediatrics, Division of Endocrinology Weill Cornell Medicine, New York Presbyterian Hospital, New York, NY, USA.

出版信息

Case Rep Endocrinol. 2021 Nov 23;2021:5930515. doi: 10.1155/2021/5930515. eCollection 2021.

DOI:10.1155/2021/5930515
PMID:34858667
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8632428/
Abstract

. Jod-Basedow Syndrome refers to a paradoxical phenomenon in which large loads of iodine can cause hyperthyroidism. It is most commonly seen in populations already at risk for thyroid disease or those with underlying kidney disease. . We present a case of an acutely ill 17-year-old boy with symptomatic hyperthyroidism following an iodinated contrast CT scan to rule out appendicitis. . This case underscores the importance of recognizing this phenomenon even in the pediatric population and in those with no preexisting history of thyroid disease. Course complications including bronchospasm, hypertension, transaminitis, and bilateral palmar desquamating rash are rare and highlight the complexities involved in the disease state and in managing side effect profiles of treatment.

摘要

碘致甲亢综合征是指大量碘可引发甲状腺功能亢进的一种矛盾现象。它最常见于已有甲状腺疾病风险的人群或患有基础肾脏疾病的人群。我们报告一例17岁急性病男孩的病例,该男孩在进行碘造影CT扫描以排除阑尾炎后出现有症状的甲状腺功能亢进。该病例强调了即使在儿科人群以及既往无甲状腺疾病史的人群中认识到这一现象的重要性。包括支气管痉挛、高血压、转氨酶升高和双侧手掌脱皮性皮疹在内的病程并发症很少见,突出了疾病状态以及治疗副作用管理方面所涉及的复杂性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b9a/8632428/01d188333c22/CRIE2021-5930515.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b9a/8632428/afeadda45b59/CRIE2021-5930515.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b9a/8632428/01d188333c22/CRIE2021-5930515.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b9a/8632428/afeadda45b59/CRIE2021-5930515.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b9a/8632428/01d188333c22/CRIE2021-5930515.002.jpg

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本文引用的文献

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Hypersensitivity Reactions to Iodinated Contrast Media: A Multicenter Study of 196 081 Patients.碘对比剂过敏反应:196081 例患者的多中心研究。
Radiology. 2019 Oct;293(1):117-124. doi: 10.1148/radiol.2019190485. Epub 2019 Sep 3.
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Severe Thyrotoxicosis Secondary to Povidone-Iodine from Peritoneal Dialysis.腹膜透析用聚维酮碘所致严重甲状腺毒症
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A possible link between the Epstein-Barr virus infection and autoimmune thyroid disorders.
硬膜外类固醇注射中使用的碘化造影剂对甲状腺功能测试的影响。
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Jod-Basedow effect due to prolonged use of lugol solution-case report.长期使用卢戈氏溶液导致的碘致甲亢效应——病例报告
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A Case Report of Post-Operative Jöd-Basedow Phenomennon Following Oral and IV Iodine Contrast Administration.口服及静脉注射碘造影剂后发生术后乔德-巴塞多现象的病例报告
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