铁死亡：攻克心脑血管疾病的新曙光

Luo Meng-Yi, Su Jian-Hui, Gong Shao-Xin, Liang Na, Huang Wen-Qian, Chen Wei, Wang Ai-Ping, Tian Ying

Institute of Clinical Research, Affiliated Nanhua Hospital, University of South China, Hengyang, China.

Hengyang Key Laboratory of Neurodegeneration and Cognitive Impairment, Department of Physiology, Institute of Neuroscience Research, Hengyang Medical College, University of South China, Hengyang, China.

Front Cell Dev Biol. 2021 Nov 11;9:733908. doi: 10.3389/fcell.2021.733908. eCollection 2021.

The dynamic balance of cardiomyocytes and neurons is essential to maintain the normal physiological functions of heart and brain. If excessive cells die in tissues, serious Cardio-Cerebrovascular Diseases would occur, namely, hypertension, myocardial infarction, and ischemic stroke. The regulation of cell death plays a role in promoting or alleviating Cardio-Cerebrovascular Diseases. Ferroptosis is an iron-dependent new type of cell death that has been proved to occur in a variety of diseases. In our review, we focus on the critical role of ferroptosis and its regulatory mechanisms involved in Cardio-Cerebrovascular Diseases, and discuss the important function of ferroptosis-related inhibitors in order to propose potential implications for the prevention and treatment of Cardio-Cerebrovascular Diseases.

心肌细胞和神经元的动态平衡对于维持心脏和大脑的正常生理功能至关重要。如果组织中过多的细胞死亡，将会发生严重的心脑血管疾病，即高血压、心肌梗死和缺血性中风。细胞死亡的调控在促进或减轻心脑血管疾病方面发挥着作用。铁死亡是一种铁依赖性的新型细胞死亡方式，已被证明在多种疾病中发生。在我们的综述中，我们聚焦于铁死亡及其调控机制在心血管疾病中的关键作用，并讨论铁死亡相关抑制剂的重要功能，以便为心脑血管疾病的预防和治疗提出潜在的启示。