Messonnier Laurent A, Chatel Benjamin, Emhoff Chi-An W, Blervaque Léo, Oyono-Enguéllé Samuel
Laboratoire Interuniversitaire de Biologie de la Motricité, Université Savoie Mont Blanc, Chambéry, France.
Cellmade Laboratories, Le Bourget-du-Lac, France.
Front Nutr. 2021 Nov 11;8:734152. doi: 10.3389/fnut.2021.734152. eCollection 2021.
Lactate constitutes the primary gluconeogenic precursor in healthy humans at rest and during low-intensity exercise. Data on the interactions between lactate and glucose metabolisms during recovery after short-duration high-intensity exercise are sparse. The aim of the present study was to describe blood glucose ([glucose]) and lactate ([lactate]) concentration curves during recovery following short-duration high-intensity exercise. Fifteen healthy Cameroonian subjects took part in the study and performed successively (i) an incremental exercise to exhaustion to determine maximal work rate (P) and (ii) a 2-min 110% P exercise after which blood lactate and glucose concentrations were measured during the 80-min passive recovery. In response to the 2-min 110% P exercise, [glucose] remained stable (from 4.93 ± 1.13 to 4.65 ± 0.74 mmolL, NS) while [lactate] increased (from 1.35 ± 0.36 to 7.87 ± 1.66 mmolL, < 0.0001). During recovery, blood lactate concentrations displayed the classic biphasic curve while blood glucose concentrations displayed a singular shape including a delayed and transitory rebound of glycemia. This rebound began at 27.7 ± 6.2 min and peaked at 6.78 ± 0.53 mmolL at 56.3 ± 9.7 min into recovery. The area under the curve (AUC) of [lactate] during the rebound of glycemia was positively correlated with the peak value of glycemia and the AUC of [glucose] during the rebound. In conclusion, the delayed rebound of glycemia observed in the present study was associated with lactate availability during this period.
在健康的静息状态及低强度运动的人体中，乳酸是糖异生的主要前体物质。关于短时间高强度运动后恢复期间乳酸与葡萄糖代谢之间相互作用的数据较为稀少。本研究的目的是描述短时间高强度运动后恢复期间的血糖（[葡萄糖]）和乳酸（[乳酸]）浓度曲线。15名健康的喀麦隆受试者参与了本研究，他们依次进行了：（i）递增运动至力竭以确定最大工作率（P）；（ii）进行2分钟110%P强度的运动，之后在80分钟的被动恢复期间测量血乳酸和血糖浓度。针对2分钟110%P强度的运动，[葡萄糖]保持稳定（从4.93±1.13降至4.65±0.74 mmol/L，无显著差异），而[乳酸]升高（从1.35±0.36升至7.87±1.66 mmol/L，P<0.0001）。在恢复过程中，血乳酸浓度呈现出经典的双相曲线，而血糖浓度呈现出独特的形状，包括血糖的延迟性和短暂性反弹。这种反弹始于27.7±6.2分钟，在恢复至56.3±9.7分钟时达到峰值6.78±0.53 mmol/L。血糖反弹期间[乳酸]的曲线下面积（AUC）与血糖峰值以及反弹期间[葡萄糖]的AUC呈正相关。总之，本研究中观察到的血糖延迟性反弹与该时期乳酸的可用性有关。
