Allen R C, St-Cyr C, Maddison P J, Ansell B M
Arch Dis Child. 1986 Mar;61(3):284-8. doi: 10.1136/adc.61.3.284.
Twenty six children with overlapping features of more than one connective tissue disorder are reported. The median age of onset was 9.5 years and median duration of follow up 7.5 years. Common presenting symptoms included arthritis, tenosynovitis. Raynaud's phenomenon, myositis, and rashes. At follow up 14 patients had developed sclerodermatous skin changes, but significant systemic involvement was uncommon. Only 16 of the 26 cases had antibodies to nuclear ribonucleoprotein; therefore, 10 did not satisfy criteria for mixed connective tissue disease. It was not possible to differentiate clinical patterns by the presence or absence of any particular antibody profile.
报告了26名具有一种以上结缔组织疾病重叠特征的儿童。发病年龄中位数为9.5岁，随访时间中位数为7.5年。常见的首发症状包括关节炎、腱鞘炎、雷诺现象、肌炎和皮疹。随访时，14例患者出现硬皮病样皮肤改变，但显著的全身受累并不常见。26例病例中只有16例有抗核核糖核蛋白抗体；因此，10例不符合混合性结缔组织病的标准。无法通过有无任何特定抗体谱来区分临床模式。
